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dc.creatorSpasojević, Nataša
dc.creatorGavrilović, Ljubica
dc.creatorJovanović, Predrag
dc.creatorDronjak, Slađana
dc.date.accessioned2018-03-01T21:56:23Z
dc.date.available2018-03-01T21:56:23Z
dc.date.issued2011
dc.identifier.issn0031-7144 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4458
dc.description.abstractChanges in gene expression of beta(i)- and beta(2)-adrenoceptors (beta(1)- and beta(2)-AR) in right and left atria and ventricles after fluoxetine treatment in stress-induced depression of adult rat males were studied. Elevated beta(1)-AR mRNA levels in the left atria and significantly higher levels of beta(2)-AR mRNA in the left atria and ventricles were observed in stress-induced depression in comparison with those of unstressed controls. Fluoxetine treatment led to increasing expression of beta(1)-AR mRNA in the right atria and left ventricles, while the level of beta(2)-AR mRNA remained unchanged. These findings suggest that fluoxetine therapy plays an important role in cardiac beta-adrenergic subsensitivity and gene regulation of beta-AR in animals with heightened sympathetic nervous activity.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.rightsrestrictedAccessen
dc.sourcePharmazieen
dc.titleFlouxetine treatment acts selectively increasing myocardial beta(1)-adrenoceptor mRNA expression in stress-induced depressionen
dc.typearticleen
dcterms.abstractЈовановић Предраг; Спасојевић Наташа; Дроњак Слађана; Гавриловић Љубица;
dc.citation.volume66
dc.citation.issue8
dc.citation.spage611
dc.citation.epage613
dc.identifier.wos000294083100011
dc.identifier.doi10.1691/ph.2011.1507
dc.citation.rankM23
dc.identifier.pmid21901985
dc.identifier.scopus2-s2.0-80053329278


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