Flouxetine treatment acts selectively increasing myocardial beta(1)-adrenoceptor mRNA expression in stress-induced depression
Abstract
Changes in gene expression of beta(i)- and beta(2)-adrenoceptors (beta(1)- and beta(2)-AR) in right and left atria and ventricles after fluoxetine treatment in stress-induced depression of adult rat males were studied. Elevated beta(1)-AR mRNA levels in the left atria and significantly higher levels of beta(2)-AR mRNA in the left atria and ventricles were observed in stress-induced depression in comparison with those of unstressed controls. Fluoxetine treatment led to increasing expression of beta(1)-AR mRNA in the right atria and left ventricles, while the level of beta(2)-AR mRNA remained unchanged. These findings suggest that fluoxetine therapy plays an important role in cardiac beta-adrenergic subsensitivity and gene regulation of beta-AR in animals with heightened sympathetic nervous activity.
Source:
Pharmazie, 2011, 66, 8, 611-613Funding / projects:
- Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-MESTD-Basic Research (BR or ON)-173044)
DOI: 10.1691/ph.2011.1507
ISSN: 0031-7144
PubMed: 21901985
WoS: 000294083100011
Scopus: 2-s2.0-80053329278
Collections
Institution/Community
VinčaTY - JOUR AU - Spasojević, Nataša AU - Gavrilović, Ljubica AU - Jovanović, Predrag AU - Dronjak, Slađana PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4458 AB - Changes in gene expression of beta(i)- and beta(2)-adrenoceptors (beta(1)- and beta(2)-AR) in right and left atria and ventricles after fluoxetine treatment in stress-induced depression of adult rat males were studied. Elevated beta(1)-AR mRNA levels in the left atria and significantly higher levels of beta(2)-AR mRNA in the left atria and ventricles were observed in stress-induced depression in comparison with those of unstressed controls. Fluoxetine treatment led to increasing expression of beta(1)-AR mRNA in the right atria and left ventricles, while the level of beta(2)-AR mRNA remained unchanged. These findings suggest that fluoxetine therapy plays an important role in cardiac beta-adrenergic subsensitivity and gene regulation of beta-AR in animals with heightened sympathetic nervous activity. T2 - Pharmazie T1 - Flouxetine treatment acts selectively increasing myocardial beta(1)-adrenoceptor mRNA expression in stress-induced depression VL - 66 IS - 8 SP - 611 EP - 613 DO - 10.1691/ph.2011.1507 ER -
@article{ author = "Spasojević, Nataša and Gavrilović, Ljubica and Jovanović, Predrag and Dronjak, Slađana", year = "2011", abstract = "Changes in gene expression of beta(i)- and beta(2)-adrenoceptors (beta(1)- and beta(2)-AR) in right and left atria and ventricles after fluoxetine treatment in stress-induced depression of adult rat males were studied. Elevated beta(1)-AR mRNA levels in the left atria and significantly higher levels of beta(2)-AR mRNA in the left atria and ventricles were observed in stress-induced depression in comparison with those of unstressed controls. Fluoxetine treatment led to increasing expression of beta(1)-AR mRNA in the right atria and left ventricles, while the level of beta(2)-AR mRNA remained unchanged. These findings suggest that fluoxetine therapy plays an important role in cardiac beta-adrenergic subsensitivity and gene regulation of beta-AR in animals with heightened sympathetic nervous activity.", journal = "Pharmazie", title = "Flouxetine treatment acts selectively increasing myocardial beta(1)-adrenoceptor mRNA expression in stress-induced depression", volume = "66", number = "8", pages = "611-613", doi = "10.1691/ph.2011.1507" }
Spasojević, N., Gavrilović, L., Jovanović, P.,& Dronjak, S.. (2011). Flouxetine treatment acts selectively increasing myocardial beta(1)-adrenoceptor mRNA expression in stress-induced depression. in Pharmazie, 66(8), 611-613. https://doi.org/10.1691/ph.2011.1507
Spasojević N, Gavrilović L, Jovanović P, Dronjak S. Flouxetine treatment acts selectively increasing myocardial beta(1)-adrenoceptor mRNA expression in stress-induced depression. in Pharmazie. 2011;66(8):611-613. doi:10.1691/ph.2011.1507 .
Spasojević, Nataša, Gavrilović, Ljubica, Jovanović, Predrag, Dronjak, Slađana, "Flouxetine treatment acts selectively increasing myocardial beta(1)-adrenoceptor mRNA expression in stress-induced depression" in Pharmazie, 66, no. 8 (2011):611-613, https://doi.org/10.1691/ph.2011.1507 . .