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dc.creatorStojanovic, Srdan D.
dc.creatorIsenović, Esma R.
dc.creatorZarić, Božidarka
dc.date.accessioned2018-03-01T21:49:44Z
dc.date.available2018-03-01T21:49:44Z
dc.date.issued2011
dc.identifier.issn1868-1743 (print)
dc.identifier.issn1868-1751 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4381
dc.description.abstractThe distinguishing property of Sm/LSm protein assemblies is their high stability. In order to better understand the nature of Sm/LSm protein oligomers in this study we have analyzed the contribution of non-canonical interactions to the stability of assemblies. The predominant types of non-canonical interactions at Sm/LSm protein interfaces are CH center dot center dot center dot O, and CH center dot center dot center dot N interactions represented at interfaces. Our results show low percentages of XH-pi and non-canonical interactions involving sulfur atoms, while the backbone groups were less frequently involved. The data show a high percentage of non-canonical interactions in interfaces formed by charged residues with Lys and Arg, these being the major charged donors. The main chain non-canonical interactions might be slightly more linear than the side chain interactions, and they have somewhat shorter median distances. Comparing the stabilizing amino acid residues with amino acids which build non-canonical interactions at interfaces shows that certain amino acids like Phe, Pro, His and Tyr are involved with a high percentage. The high conservation score of amino acids that are involved in non-canonical interactions in protein interfaces is an additional strong argument for their importance in the stabilization of Sm/LSm protein assemblies.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172001/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS//
dc.rightsrestrictedAccessen
dc.sourceMolecular Informaticsen
dc.subjectComputational chemistryen
dc.subjectInterfacesen
dc.subjectNoncovalent interactionsen
dc.subjectProteinsen
dc.subjectStabilization centersen
dc.titleContribution of Non-Canonical Interactions to the Stability of Sm/LSm Oligomeric Assembliesen
dc.typearticleen
dcterms.abstractИсеновић Есма; Зарић Божидарка; Стојановиц, Срдан Д.;
dc.citation.volume30
dc.citation.issue5
dc.citation.spage430
dc.citation.epage442
dc.identifier.wos000291602600005
dc.identifier.doi10.1002/minf.201000176
dc.citation.rankM21
dc.identifier.pmid27467089
dc.identifier.scopus2-s2.0-79958792930


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