Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one
2013
Autori
Smit, BiljanaPavlović, Radoslav Z.
Radosavljević-Mihajlović, Ana S.
Došen, Anja M.
Curcic, Milena G.
Seklic, Dragana S.
Živanović, Marko N.
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The polydentate ligand 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one was synthesized in the intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethyl chloroacetate. A novel palladium(II) complex was obtained from cis-[Pd(DMSO)(2)Cl-2] by nucleophilic substitution of both DMSO ligands with the iminic nitrogen and the thiolactamic sulfur from the ligand. The structures of the compounds were characterized based on their spectral data. The cytotoxic activities of the ligand and the palladium(II) complex were studied on the tumor cell lines: human colon carcinoma HCT-116 and SW-480 cells using the MTT viability test. The results showed that the investigated palladium(II) complex had a significantly greater cytotoxic effect compared to that of the ligand.
Ključne reči:
thiohydantoins / palladium(II) complexes / cytotoxic activityIzvor:
Journal of the Serbian Chemical Society, 2013, 78, 2, 217-227Finansiranje / projekti:
- Ispitivanje mehanizma reakcija kompleksa jona prelaznih metala sa biološki značajnim molekulima (RS-MESTD-Basic Research (BR or ON)-172011)
- Preklinička ispitivanja bioaktivnih supstanci (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41010)
DOI: 10.2298/JSC120725154S
ISSN: 0352-5139
WoS: 000315607000007
Scopus: 2-s2.0-84874620305
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Smit, Biljana AU - Pavlović, Radoslav Z. AU - Radosavljević-Mihajlović, Ana S. AU - Došen, Anja M. AU - Curcic, Milena G. AU - Seklic, Dragana S. AU - Živanović, Marko N. PY - 2013 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4370 AB - The polydentate ligand 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one was synthesized in the intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethyl chloroacetate. A novel palladium(II) complex was obtained from cis-[Pd(DMSO)(2)Cl-2] by nucleophilic substitution of both DMSO ligands with the iminic nitrogen and the thiolactamic sulfur from the ligand. The structures of the compounds were characterized based on their spectral data. The cytotoxic activities of the ligand and the palladium(II) complex were studied on the tumor cell lines: human colon carcinoma HCT-116 and SW-480 cells using the MTT viability test. The results showed that the investigated palladium(II) complex had a significantly greater cytotoxic effect compared to that of the ligand. T2 - Journal of the Serbian Chemical Society T1 - Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one VL - 78 IS - 2 SP - 217 EP - 227 DO - 10.2298/JSC120725154S ER -
@article{ author = "Smit, Biljana and Pavlović, Radoslav Z. and Radosavljević-Mihajlović, Ana S. and Došen, Anja M. and Curcic, Milena G. and Seklic, Dragana S. and Živanović, Marko N.", year = "2013", abstract = "The polydentate ligand 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one was synthesized in the intermolecular cyclocondensation reaction of 2-hydroxybenzaldehyde thiosemicarbazone and ethyl chloroacetate. A novel palladium(II) complex was obtained from cis-[Pd(DMSO)(2)Cl-2] by nucleophilic substitution of both DMSO ligands with the iminic nitrogen and the thiolactamic sulfur from the ligand. The structures of the compounds were characterized based on their spectral data. The cytotoxic activities of the ligand and the palladium(II) complex were studied on the tumor cell lines: human colon carcinoma HCT-116 and SW-480 cells using the MTT viability test. The results showed that the investigated palladium(II) complex had a significantly greater cytotoxic effect compared to that of the ligand.", journal = "Journal of the Serbian Chemical Society", title = "Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one", volume = "78", number = "2", pages = "217-227", doi = "10.2298/JSC120725154S" }
Smit, B., Pavlović, R. Z., Radosavljević-Mihajlović, A. S., Došen, A. M., Curcic, M. G., Seklic, D. S.,& Živanović, M. N.. (2013). Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one. in Journal of the Serbian Chemical Society, 78(2), 217-227. https://doi.org/10.2298/JSC120725154S
Smit B, Pavlović RZ, Radosavljević-Mihajlović AS, Došen AM, Curcic MG, Seklic DS, Živanović MN. Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one. in Journal of the Serbian Chemical Society. 2013;78(2):217-227. doi:10.2298/JSC120725154S .
Smit, Biljana, Pavlović, Radoslav Z., Radosavljević-Mihajlović, Ana S., Došen, Anja M., Curcic, Milena G., Seklic, Dragana S., Živanović, Marko N., "Synthesis, characterization and cytotoxicity of a palladium(II) complex of 3-[(2-hydroxybenzylidene)amino]-2-thioxoimidazolidin-4-one" in Journal of the Serbian Chemical Society, 78, no. 2 (2013):217-227, https://doi.org/10.2298/JSC120725154S . .