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dc.creatorSadowski, Jerzy
dc.creatorBartus, Krzysztof
dc.creatorKapelak, Boguslaw
dc.creatorRocha-Singh, Krishna J.
dc.creatorKatholi, Richard E.
dc.creatorWitkowski, Adam
dc.creatorKadziela, Jacek
dc.creatorJanuszewicz, Andrzej
dc.creatorPrejbisz, Aleksander
dc.creatorWalton, Anthony S.
dc.creatorSievert, Horst
dc.creatorId, Dani
dc.creatorWunderlich, Nina
dc.creatorWhitbourn, Robert
dc.creatorRump, Lars Christian
dc.creatorVonend, Oliver
dc.creatorSaleh, Andreas
dc.creatorThambar, Suku
dc.creatorNanra, Ranjit
dc.creatorZeller, Thomas
dc.creatorErglis, Andrejs
dc.creatorSagic, Dragan
dc.creatorBoskovic, Srdjan
dc.creatorBrachmann, Johannes
dc.creatorSchmidt, Martin
dc.creatorWenzel, Ulrich O.
dc.creatorBart, Bradley A.
dc.creatorSchmieder, Roland E.
dc.creatorScheinert, Dierk
dc.creatorBoergel, Jan
dc.creatorStraley, Craig
dc.creatorSymplicity HTN-1 Investigators
dc.date.accessioned2018-03-01T21:41:21Z
dc.date.available2018-03-01T21:41:21Z
dc.date.issued2011
dc.identifier.issn0194-911X (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/123456789/4283
dc.description.abstractRenal sympathetic hyperactivity is seminal in the maintenance and progression of hypertension. Catheter-based renal sympathetic denervation has been shown to significantly reduce blood pressure (BP) in patients with hypertension. Durability of effect beyond 1 year using this novel technique has never been reported. A cohort of 45 patients with resistant hypertension (systolic BP GT = 160 mm Hg on GT = 3 antihypertension drugs, including a diuretic) has been originally published. Herein, we report longer-term follow-up data on these and a larger group of similar patients subsequently treated with catheter-based renal denervation in a nonrandomized manner. We treated 153 patients with catheter-based renal sympathetic denervation at 19 centers in Australia, Europe, and the United States. Mean age was 57 +/- 11 years, 39% were women, 31% were diabetic, and 22% had coronary artery disease. Baseline values included mean office BP of 176/98 +/- 17/15 mm Hg, mean of 5 antihypertension medications, and an estimated glomerular filtration rate of 83 +/- 20 mL/min per 1.73 m(2). The median time from first to last radiofrequency energy ablation was 38 minutes. The procedure was without complication in 97% of patients (149 of 153). The 4 acute procedural complications included 3 groin pseudoaneurysms and 1 renal artery dissection, all managed without further sequelae. Postprocedure office BPs were reduced by 20/10, 24/11, 25/11, 23/11, 26/14, and 32/14 mm Hg at 1, 3, 6, 12, 18, and 24 months, respectively. In conclusion, in patients with resistant hypertension, catheter-based renal sympathetic denervation results in a substantial reduction in BP sustained out to GT = 2 years of follow-up, without significant adverse events. (Hypertension. 2011;57:911-917.)en
dc.relationArdian, Inc.
dc.rightsopenAccessen
dc.sourceHypertensionen
dc.subjecthypertensionen
dc.subjectblood pressureen
dc.subjectrenal sympathetic denervationen
dc.titleCatheter-Based Renal Sympathetic Denervation for Resistant Hypertension Durability of Blood Pressure Reduction Out to 24 Monthsen
dc.typearticleen
dcterms.abstractСадоwски, Јерзy; Бартус, Крзyсзтоф; Капелак, Богуслаw; Роцха-Сингх, Крисхна Ј.; Катхоли, Рицхард Е.; Wиткоwски, Aдам; Кадзиела, Јацек; Јанусзеwицз, Aндрзеј; Прејбисз, Aлександер; Wалтон, Aнтхонy С.; Сиеверт, Хорст; Ид, Дани; Wундерлицх, Нина; Wхитбоурн, Роберт; Румп, Ларс Цхристиан; Воненд, Оливер; Салех, Aндреас; Тхамбар, Суку; Нанра, Рањит; Зеллер, Тхомас; Ерглис, Aндрејс; Сагиц, Драган; Босковиц, Срдјан; Брацхманн, Јоханнес; Сцхмидт, Мартин; Wензел, Улрицх О.; Барт, Брадлеy A.; Сцхмиедер, Роланд Е.; Сцхеинерт, Диерк; Боергел, Јан; Стралеy, Цраиг; Сyмплицитy ХТН-1 Инвестигаторс;
dc.citation.volume57
dc.citation.issue5
dc.citation.spage911
dc.citation.epage917
dc.identifier.wos000289730200017
dc.identifier.doi10.1161/HYPERTENSIONAHA.110.163014
dc.citation.rankM21a
dc.identifier.scopus2-s2.0-79955477242
dc.identifier.fulltexthttp://vinar.rcub.bg.ac.rs/bitstream/handle/123456789/4283/4279.pdf


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