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dc.creatorElaković, Ivana
dc.creatorĐorđević, Ana D.
dc.creatorAdžić, Miroslav
dc.creatorĐorđević, Jelena D.
dc.creatorRadojčić, Marija
dc.creatorMatić, Gordana
dc.date.accessioned2018-03-01T21:40:49Z
dc.date.available2018-03-01T21:40:49Z
dc.date.issued2011
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/4277
dc.description.abstractGender-related differences in dexamethasone binding to corticosteroid receptors (CR) and in glucocorticoid receptor (GR) protein level in the pituitary, hypothalamus, hippocampus and prefrontal cortex were studied before and after antidepressant fluoxetine administration to both unstressed and rats exposed to a chronic social isolation stress. Untreated males, in comparison to females, displayed higher hormone-binding capacity of both GR and mineralocorticoid receptor (MR) in the hippocampal cytosol, as well as higher GR protein level in the pituitary cytosol. In both genders, dexamethasone binding to MR exceeded that to GR. While fluoxetine treatment and social isolation had no effect on GR activity, the influence on MR was gender-specific. Fluoxetine facilitated MR hormone-binding only in females, increasing the MR/GA activity ratio. In contrast, after a 6-week isolation of males, MR binding capacity was diminished and MR/GR ratio inverted in favor of GR In addition, fluoxetine induced elevation of cytosolic GR protein level in the pituitary and hypothalamus, the latter change being gender-specific. The results point to gender-related differences in the CRs functioning and suggest that both MR and GR may contribute to well-known sexual dimorphism in vulnerability to stress and stress-related disorders and in the outcome of antidepressant treatment. (C) 2011 Elsevier B.V. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41029/RS//
dc.rightsrestrictedAccessen
dc.sourceBrain Researchen
dc.subjectGlucocorticoid receptoren
dc.subjectMineralocorticoid receptoren
dc.subjectGender differencesen
dc.subjectAntidepressant fluoxetineen
dc.subjectSocial isolation stressen
dc.titleGender-specific response of brain corticosteroid receptors to stress and fluoxetineen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractЕлаковиц, Ивана; Ђорђевић Aна Д; Aджић Мирослав; Ђорђевић Јелена Д.; Радоичић Марија; Матиц, Гордана;
dc.citation.volume1384
dc.citation.spage61
dc.citation.epage68
dc.identifier.wos000289543100008
dc.identifier.doi10.1016/j.brainres.2011.01.078
dc.citation.rankM23
dc.identifier.pmid21281618
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-79953024327


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