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dc.creatorVeljković, Veljko
dc.creatorGlišić, Sanja
dc.creatorMuller, Claude P.
dc.creatorScotch, Matthew
dc.creatorBranch, Donald R.
dc.creatorPerović, Vladimir R.
dc.creatorSenćanski, Milan V.
dc.creatorVeljković, Nevena V.
dc.creatorColombatti, Alfonso
dc.date.accessioned2018-03-01T15:57:19Z
dc.date.available2018-03-01T15:57:19Z
dc.date.issued2015
dc.identifier.issn1664-302X (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/423
dc.description.abstractThe worst Ebola virus (EV) outbreak in history has hit Liberia, Sierra Leone and Guinea hardest and the trend lines in this crisis are grave, and now represents a global public health threat concern. Limited therapeutic and/or prophylactic options are available for people suffering from Ebola virus disease (EVD) and further complicate the situation. Previous studies suggested that the EV glycoprotein (GP) is the main determinant causing structural damage of endothelial cells that triggers the hemorrhagic diathesis, but molecular mechanisms underlying this phenomenon remains elusive. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of the protein-protein interactions, the interaction of GP with endothelial extracellular matrix (ECM) was investigated. Presented results of this in silico study suggest that Elastin Microfibril Interface Located Proteins (EMILINs) are involved in interaction between GP and ECM. This finding could contribute to a better understanding of EV/endothelium interaction and its role in pathogenesis, prevention and therapy of EVD.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173001/RS//
dc.rightsopenAccessen
dc.sourceFrontiers in Microbiologyen
dc.subjectEbola virusen
dc.subjectglycoprotein GPen
dc.subjectendothelial extracellular matrixen
dc.subjectEMILINsen
dc.subjectin silico analysisen
dc.titleIn silico analysis suggests interaction between Ebola virus and the extracellular matrixen
dc.typearticleen
dcterms.abstractВељковић Вељко; Сенчански Милан В.; Сцотцх, Маттхеw; Муллер, Цлауде П.; Бранцх, Доналд Р.; Цоломбатти, Aлфонсо; Глишић Сања; Перовић Владимир; Вељковић Невена В.;
dc.citation.volume6
dc.identifier.wos000350310200001
dc.identifier.doi10.3389/fmicb.2015.00135
dc.citation.otherArticle Number: 135
dc.citation.rankM21
dc.identifier.pmid25745423
dc.identifier.scopus2-s2.0-84927523630
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/4877/fmicb-06-00135.pdf


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