Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery
Nema prikaza
Autori
Vukomanovic, MarijaŠkapin, Srečo Davor
Jančar, Boštjan
Maksin, Tatjana N.
Ignjatović, Nenad L.
Uskokovic, Vuk
Uskoković, Dragan
Članak u časopisu
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the ...kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.
Ključne reči:
Core-shells / Drug delivery / Multifunctional materials / Poly(D,L-lactide-co-glycolide)/hydroxyapatite / Ultrasonic processingIzvor:
Colloids and Surfaces. B: Biointerfaces, 2011, 82, 2, 404-413Finansiranje / projekti:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
DOI: 10.1016/j.colsurfb.2010.09.011
ISSN: 0927-7765; 1873-4367
PubMed: 20951005
WoS: 000285858200021
Scopus: 2-s2.0-78649442520
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Vukomanovic, Marija AU - Škapin, Srečo Davor AU - Jančar, Boštjan AU - Maksin, Tatjana N. AU - Ignjatović, Nenad L. AU - Uskokovic, Vuk AU - Uskoković, Dragan PY - 2011 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4188 AB - Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved. T2 - Colloids and Surfaces. B: Biointerfaces T1 - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery VL - 82 IS - 2 SP - 404 EP - 413 DO - 10.1016/j.colsurfb.2010.09.011 ER -
@article{ author = "Vukomanovic, Marija and Škapin, Srečo Davor and Jančar, Boštjan and Maksin, Tatjana N. and Ignjatović, Nenad L. and Uskokovic, Vuk and Uskoković, Dragan", year = "2011", abstract = "Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.", journal = "Colloids and Surfaces. B: Biointerfaces", title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery", volume = "82", number = "2", pages = "404-413", doi = "10.1016/j.colsurfb.2010.09.011" }
Vukomanovic, M., Škapin, S. D., Jančar, B., Maksin, T. N., Ignjatović, N. L., Uskokovic, V.,& Uskoković, D.. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces. B: Biointerfaces, 82(2), 404-413. https://doi.org/10.1016/j.colsurfb.2010.09.011
Vukomanovic M, Škapin SD, Jančar B, Maksin TN, Ignjatović NL, Uskokovic V, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. in Colloids and Surfaces. B: Biointerfaces. 2011;82(2):404-413. doi:10.1016/j.colsurfb.2010.09.011 .
Vukomanovic, Marija, Škapin, Srečo Davor, Jančar, Boštjan, Maksin, Tatjana N., Ignjatović, Nenad L., Uskokovic, Vuk, Uskoković, Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery" in Colloids and Surfaces. B: Biointerfaces, 82, no. 2 (2011):404-413, https://doi.org/10.1016/j.colsurfb.2010.09.011 . .