NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid
Samo za registrovane korisnike
2014
Autori
Babić-Stojić, Branka S.Jokanović, Vukoman R.
Milivojević, Dušan
Pozek, Miroslav
Jagličić, Zvonko
Makovec, Darko
Arsikin, Katarina M.
Paunović, Verica G.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Gd2O3 nanoparticles and their agglomerates from approximately 10 to 80 nm in size suspended in an organic liquid were synthesized via polyol route. The reaction between diethylene glycol and added acetic acid, which occurred simultaneously with the synthesis of Gd2O3 nanoparticles, was catalyzed by sodium bisulfate to transform as much as possible diethylene glycol in corresponding ester at the end of complete reaction. The produced nanosized material of gadolinium oxide was investigated by TEM, DLS, FTIR spectroscopy, and NMR relaxometry. Biological evaluation of this material was done by MTT and crystal violet assays to determine the cell viability. Longitudinal and transverse relaxivities of water-diluted Gd2O3 nanoparticle suspensions estimated to be r(1) = 13.6 and r(2) = 14.7 s(-1) mM(-1) are about three times higher compared to the relaxivities obtained for standard contrast agent Gd-DTPA (Magnevist). Good MRI signal intensities of the water-diluted Gd2O3 nanoparticle suspension...s were recorded in the Gd concentration range 0.2-0.3 mM for which the suspensions were not toxic exhibiting simultaneously higher signal intensities than those for Magnevist in the Gd concentration range 0.4-1 mM for which this standard contrast agent was not toxic. These properties make the produced Gd2O3 nanoparticle material promising for potential application as MRI contrast agent.
Ključne reči:
Gadolinium oxide / Nanoparticles / Relaxivity / Magnetic resonance imaging / Contrast agents / Toxicity / Environmental and health effectsIzvor:
Journal of Nanoparticle Research, 2014, 16, 10Finansiranje / projekti:
- Hemijsko i strukturno dizajniranje nanomaterijala za primenu u medicini i inženjerstvu tkiva (RS-172026)
- Modulacija signalnih puteva koji kontrolišu intracelularni energetski balans u terapiji tumora i neuro-imuno-endokrinih poremećaja (RS-41025)
DOI: 10.1007/s11051-014-2663-0
ISSN: 1388-0764; 1572-896X
WoS: 000349951900001
Scopus: 2-s2.0-84919905573
Institucija/grupa
VinčaTY - JOUR AU - Babić-Stojić, Branka S. AU - Jokanović, Vukoman R. AU - Milivojević, Dušan AU - Pozek, Miroslav AU - Jagličić, Zvonko AU - Makovec, Darko AU - Arsikin, Katarina M. AU - Paunović, Verica G. PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/414 AB - Gd2O3 nanoparticles and their agglomerates from approximately 10 to 80 nm in size suspended in an organic liquid were synthesized via polyol route. The reaction between diethylene glycol and added acetic acid, which occurred simultaneously with the synthesis of Gd2O3 nanoparticles, was catalyzed by sodium bisulfate to transform as much as possible diethylene glycol in corresponding ester at the end of complete reaction. The produced nanosized material of gadolinium oxide was investigated by TEM, DLS, FTIR spectroscopy, and NMR relaxometry. Biological evaluation of this material was done by MTT and crystal violet assays to determine the cell viability. Longitudinal and transverse relaxivities of water-diluted Gd2O3 nanoparticle suspensions estimated to be r(1) = 13.6 and r(2) = 14.7 s(-1) mM(-1) are about three times higher compared to the relaxivities obtained for standard contrast agent Gd-DTPA (Magnevist). Good MRI signal intensities of the water-diluted Gd2O3 nanoparticle suspensions were recorded in the Gd concentration range 0.2-0.3 mM for which the suspensions were not toxic exhibiting simultaneously higher signal intensities than those for Magnevist in the Gd concentration range 0.4-1 mM for which this standard contrast agent was not toxic. These properties make the produced Gd2O3 nanoparticle material promising for potential application as MRI contrast agent. T2 - Journal of Nanoparticle Research T1 - NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid VL - 16 IS - 10 DO - 10.1007/s11051-014-2663-0 ER -
@article{ author = "Babić-Stojić, Branka S. and Jokanović, Vukoman R. and Milivojević, Dušan and Pozek, Miroslav and Jagličić, Zvonko and Makovec, Darko and Arsikin, Katarina M. and Paunović, Verica G.", year = "2014", abstract = "Gd2O3 nanoparticles and their agglomerates from approximately 10 to 80 nm in size suspended in an organic liquid were synthesized via polyol route. The reaction between diethylene glycol and added acetic acid, which occurred simultaneously with the synthesis of Gd2O3 nanoparticles, was catalyzed by sodium bisulfate to transform as much as possible diethylene glycol in corresponding ester at the end of complete reaction. The produced nanosized material of gadolinium oxide was investigated by TEM, DLS, FTIR spectroscopy, and NMR relaxometry. Biological evaluation of this material was done by MTT and crystal violet assays to determine the cell viability. Longitudinal and transverse relaxivities of water-diluted Gd2O3 nanoparticle suspensions estimated to be r(1) = 13.6 and r(2) = 14.7 s(-1) mM(-1) are about three times higher compared to the relaxivities obtained for standard contrast agent Gd-DTPA (Magnevist). Good MRI signal intensities of the water-diluted Gd2O3 nanoparticle suspensions were recorded in the Gd concentration range 0.2-0.3 mM for which the suspensions were not toxic exhibiting simultaneously higher signal intensities than those for Magnevist in the Gd concentration range 0.4-1 mM for which this standard contrast agent was not toxic. These properties make the produced Gd2O3 nanoparticle material promising for potential application as MRI contrast agent.", journal = "Journal of Nanoparticle Research", title = "NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid", volume = "16", number = "10", doi = "10.1007/s11051-014-2663-0" }
Babić-Stojić, B. S., Jokanović, V. R., Milivojević, D., Pozek, M., Jagličić, Z., Makovec, D., Arsikin, K. M.,& Paunović, V. G.. (2014). NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid. in Journal of Nanoparticle Research, 16(10). https://doi.org/10.1007/s11051-014-2663-0
Babić-Stojić BS, Jokanović VR, Milivojević D, Pozek M, Jagličić Z, Makovec D, Arsikin KM, Paunović VG. NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid. in Journal of Nanoparticle Research. 2014;16(10). doi:10.1007/s11051-014-2663-0 .
Babić-Stojić, Branka S., Jokanović, Vukoman R., Milivojević, Dušan, Pozek, Miroslav, Jagličić, Zvonko, Makovec, Darko, Arsikin, Katarina M., Paunović, Verica G., "NMR relaxometric properties and cytotoxicity of Gd2O3 nanoparticle suspensions in an organic liquid" in Journal of Nanoparticle Research, 16, no. 10 (2014), https://doi.org/10.1007/s11051-014-2663-0 . .