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dc.creatorLazarević-Pašti, Tamara
dc.creatorMomić, Tatjana
dc.creatorOnjia, Antonije E.
dc.creatorVujisic, Ljubodrag
dc.creatorVasić, Vesna M.
dc.date.accessioned2018-03-01T21:21:23Z
dc.date.available2018-03-01T21:21:23Z
dc.date.issued2010
dc.identifier.issn0026-3672 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4092
dc.description.abstractIn order to improve the sensitivity of assays for inhibitors of the enzyme acetylcholine esterase (AChE), an effective method was developed for the conversion of the organophosphate pesticides (OPs) diazinon, malathion, chlorpyrifos, azinphos-methyl and phorate into more toxic inhibitors. This was accomplished by converting them from the thio form into their oxo form using the enzyme myeloperoxidase. The oxo forms, which are the only products of conversion, were determined by AChE bioassays, using either the free enzyme, or a flow injection analysis manifold with immobilized AChE and spectrophotometric detection. All modified OPs exhibited inhibitory power at ppb levels and within 10 min. The method is considered to represent an excellent means for improving the sensitivity of assays for determination of OPs.en
dc.relationMinistry of Science and Environmental Protection of the Republic of Serbia
dc.rightsrestrictedAccessen
dc.sourceMicrochimica Actaen
dc.subjectOrganophosphate pesticidesen
dc.subjectMyeloperoxidaseen
dc.subjectOxidationen
dc.subjectBioanalyticsen
dc.subjectAcethylcholinesteraseen
dc.titleMyeloperoxidase-mediated oxidation of organophosphorus pesticides as a pre-step in their determination by AChE based bioanalytical methodsen
dc.typearticleen
dcterms.abstractОњиа, Aнтоније; Лазаревић-Пасти Тамара; Момић Татјана; Вујисиц, Љубодраг; Васић Весна М;
dc.citation.volume170
dc.citation.issue3-4
dc.citation.spage289
dc.citation.epage297
dc.identifier.wos000281384000011
dc.identifier.doi10.1007/s00604-010-0324-2
dc.citation.rankM22
dc.identifier.scopus2-s2.0-77956180737


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