Chronic Social Isolation Suppresses Proplastic Response and Promotes Proapoptotic Signalling in Prefrontal Cortex of Wistar Rats
Само за регистроване кориснике
2010
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Successful adaptation to stress involves synergized actions of glucocorticoids and catecholamines at several levels of the CNS, including the prefrontal cortex (PFC). Inside the PFC, hormonal signals trigger concerted actions of transcriptional factors, such as glucocorticoid receptor (GR) and nuclear factor kappa B (NF kappa B), culminating in a balanced, proadaptive expression of their common genes, such as proplastic NCAM and/or apoptotic Bax and Bcl-2. In the present study, we hypothesized that chronic stress may compromise the balance between GR and NF kappa B signals and lead to an altered/maladaptive expression of their cognate genes in the PFC. Our results obtained with Wistar rats exposed to chronic social isolation indicated alterations of the GR relative to the NF kappa B, in favor of the GA, in both the cytoplasmic and the nuclear compartments of the PFC. Although these alterations did not affect the induction of proplastic NCAM gene, they decreased the NCAM sialylation nec...essary for plastic response and caused marked relocation of the mitochondrial membrane antiapoptotic Bcl-2 protein to its cytoplasmic form. Moreover, the compromised PSA-NCAM plastic response found under chronic stress was sustained after exposure of animals to the subsequent acute stress, whereas the proapoptotic signals were further emphasized. It is concluded that chronic social isolation of Wistar animals leads to a maladaptive response of the PFC, considering the diminishment of its plastic potential and potentiating of apoptosis. Such conditions in the PFC are likely to compromise its ability to interact with other CNS structures, such as the hippocampus, which is necessary for successful adaptation to stress. (C) 2010 Wiley-Liss, Inc.
Кључне речи:
glucocorticoid receptor / NR kappa B / PSA-NCAM / Bax / Bcl-2Извор:
Journal of Neuroscience Research, 2010, 88, 11, 2524-2533Финансирање / пројекти:
- Одговор сисарских ћелија на ендокрини и радиобиолошки стрес (RS-MESTD-MPN2006-2010-143042)
DOI: 10.1002/jnr.22403
ISSN: 0360-4012
PubMed: 20623537
WoS: 000280436600021
Scopus: 2-s2.0-77955358380
Колекције
Институција/група
VinčaTY - JOUR AU - Đorđević, Ana D. AU - Adžić, Miroslav AU - Đorđević, Jelena D. AU - Radojčić, Marija PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4060 AB - Successful adaptation to stress involves synergized actions of glucocorticoids and catecholamines at several levels of the CNS, including the prefrontal cortex (PFC). Inside the PFC, hormonal signals trigger concerted actions of transcriptional factors, such as glucocorticoid receptor (GR) and nuclear factor kappa B (NF kappa B), culminating in a balanced, proadaptive expression of their common genes, such as proplastic NCAM and/or apoptotic Bax and Bcl-2. In the present study, we hypothesized that chronic stress may compromise the balance between GR and NF kappa B signals and lead to an altered/maladaptive expression of their cognate genes in the PFC. Our results obtained with Wistar rats exposed to chronic social isolation indicated alterations of the GR relative to the NF kappa B, in favor of the GA, in both the cytoplasmic and the nuclear compartments of the PFC. Although these alterations did not affect the induction of proplastic NCAM gene, they decreased the NCAM sialylation necessary for plastic response and caused marked relocation of the mitochondrial membrane antiapoptotic Bcl-2 protein to its cytoplasmic form. Moreover, the compromised PSA-NCAM plastic response found under chronic stress was sustained after exposure of animals to the subsequent acute stress, whereas the proapoptotic signals were further emphasized. It is concluded that chronic social isolation of Wistar animals leads to a maladaptive response of the PFC, considering the diminishment of its plastic potential and potentiating of apoptosis. Such conditions in the PFC are likely to compromise its ability to interact with other CNS structures, such as the hippocampus, which is necessary for successful adaptation to stress. (C) 2010 Wiley-Liss, Inc. T2 - Journal of Neuroscience Research T1 - Chronic Social Isolation Suppresses Proplastic Response and Promotes Proapoptotic Signalling in Prefrontal Cortex of Wistar Rats VL - 88 IS - 11 SP - 2524 EP - 2533 DO - 10.1002/jnr.22403 ER -
@article{ author = "Đorđević, Ana D. and Adžić, Miroslav and Đorđević, Jelena D. and Radojčić, Marija", year = "2010", abstract = "Successful adaptation to stress involves synergized actions of glucocorticoids and catecholamines at several levels of the CNS, including the prefrontal cortex (PFC). Inside the PFC, hormonal signals trigger concerted actions of transcriptional factors, such as glucocorticoid receptor (GR) and nuclear factor kappa B (NF kappa B), culminating in a balanced, proadaptive expression of their common genes, such as proplastic NCAM and/or apoptotic Bax and Bcl-2. In the present study, we hypothesized that chronic stress may compromise the balance between GR and NF kappa B signals and lead to an altered/maladaptive expression of their cognate genes in the PFC. Our results obtained with Wistar rats exposed to chronic social isolation indicated alterations of the GR relative to the NF kappa B, in favor of the GA, in both the cytoplasmic and the nuclear compartments of the PFC. Although these alterations did not affect the induction of proplastic NCAM gene, they decreased the NCAM sialylation necessary for plastic response and caused marked relocation of the mitochondrial membrane antiapoptotic Bcl-2 protein to its cytoplasmic form. Moreover, the compromised PSA-NCAM plastic response found under chronic stress was sustained after exposure of animals to the subsequent acute stress, whereas the proapoptotic signals were further emphasized. It is concluded that chronic social isolation of Wistar animals leads to a maladaptive response of the PFC, considering the diminishment of its plastic potential and potentiating of apoptosis. Such conditions in the PFC are likely to compromise its ability to interact with other CNS structures, such as the hippocampus, which is necessary for successful adaptation to stress. (C) 2010 Wiley-Liss, Inc.", journal = "Journal of Neuroscience Research", title = "Chronic Social Isolation Suppresses Proplastic Response and Promotes Proapoptotic Signalling in Prefrontal Cortex of Wistar Rats", volume = "88", number = "11", pages = "2524-2533", doi = "10.1002/jnr.22403" }
Đorđević, A. D., Adžić, M., Đorđević, J. D.,& Radojčić, M.. (2010). Chronic Social Isolation Suppresses Proplastic Response and Promotes Proapoptotic Signalling in Prefrontal Cortex of Wistar Rats. in Journal of Neuroscience Research, 88(11), 2524-2533. https://doi.org/10.1002/jnr.22403
Đorđević AD, Adžić M, Đorđević JD, Radojčić M. Chronic Social Isolation Suppresses Proplastic Response and Promotes Proapoptotic Signalling in Prefrontal Cortex of Wistar Rats. in Journal of Neuroscience Research. 2010;88(11):2524-2533. doi:10.1002/jnr.22403 .
Đorđević, Ana D., Adžić, Miroslav, Đorđević, Jelena D., Radojčić, Marija, "Chronic Social Isolation Suppresses Proplastic Response and Promotes Proapoptotic Signalling in Prefrontal Cortex of Wistar Rats" in Journal of Neuroscience Research, 88, no. 11 (2010):2524-2533, https://doi.org/10.1002/jnr.22403 . .