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Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study
dc.creator | Kurtovic, Nada Kraguljac | |
dc.creator | Krajnović, Milena M. | |
dc.creator | Dimitrijević, Bogomir B. | |
dc.creator | Mihaljevic, Biljana | |
dc.creator | Gotić, Mirjana | |
dc.creator | Krtolica-Žikić, Koviljka | |
dc.date.accessioned | 2018-03-01T21:17:22Z | |
dc.date.available | 2018-03-01T21:17:22Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0354-4664 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/4045 | |
dc.description.abstract | The methylation status of the target promoter sequences of p15(INK4B) (p15) and O-6-methylguanine-DNA methyltransferase (MGMT) genes was studied by methylation-specific PCR in 10 adult patients with de novo B-cell non-Hodgkin lymphoma (B-NHL). The aberrant hypermethylation of the p15 gene was more frequent (50%) compared to the hypermethylation of the MGMT gene (30%), and was detected in different types of B-NHL in both genes. Hypermethylation of the MGMT gene occurred exclusively in association with the hypermethylation of the p15 gene. All lymphoma patients with hypermethylation of the p15 and/or MGMT genes had a higher clinical stage of the disease (IV - V). We show the association of anemia and/or thrombocytopenia with the hypermethylation of the p15 gene, ascribing the p15 gene as a potential prognostic marker in B-NHL. Comethylation of MGMT with the p15 gene represents a novel finding and presents both genes as candidates for future studies of the hypermethylation profiles of B-NHL. | en |
dc.relation | Ministry of Science and Technology of the Republic of Serbia [143010] | |
dc.rights | openAccess | en |
dc.source | Archives of Biological Sciences | en |
dc.subject | Methylation status | en |
dc.subject | p15(INK4B) | en |
dc.subject | O-6-methylguanine-DNA methyltransferase | en |
dc.subject | B-cell non-Hodgkin lymphoma | en |
dc.title | Frequency of Aberrant Promoter Methylation of P15(Ink4b) and O-6-Methylguanine-Dna Methyltransferase Genes in B-Cell Non-Hodgkin Lymphoma: a Pilot Study | en |
dc.type | article | en |
dcterms.abstract | Куртовиц, Нада Крагуљац; Михаљевиц, Биљана; Готиц, Мирјана; Кртолица, Ковиљка; Крајновић Милена; Димитријевић Богомир Б.; | |
dc.citation.volume | 62 | |
dc.citation.issue | 2 | |
dc.citation.spage | 211 | |
dc.citation.epage | 221 | |
dc.identifier.wos | 000280017400002 | |
dc.identifier.doi | 10.2298/ABS1002211K | |
dc.citation.rank | M23 | |
dc.identifier.scopus | 2-s2.0-77955148901 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs//bitstream/id/12641/4041.pdf |