Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing
AuthorsFouad, Hanan H.
Bakhoum, Sameh W.
Rashed, Laila A.
Sayed, Rehab H.
Rateb, Moshira A.
Haidara, Mohamed A.
Soskić, Sanja S.
Isenović, Esma R.
MetadataShow full item record
We determined the serum levels of soluble CD40 ligand (sCD4OL) in patients with chronic coronary artery disease (CAD) and acute coronary syndrome (ACS). Patients with unstable angina (UA) and myocardial infarction (MI) showed significantly higher levels (P LT .001) of sCD4OL compared with patients with stable angina (SA) and controls; particularly, high levels occurred in patients with UA (UA: 9.23 +/- 2.92, MI: 7.38 +/- 1.05, SA: 4.42 +/- 1.08; control: 4.01 +/- 0.87 ng/mL). There was no significant difference in sCD4OL levels between patients with UA and MI or between patients with SA and controls. Levels of sCD4OL did not show any significant correlation with peak creatine kinase (CK), CK-MB isoenzyme activity in patients with MI, troponin T serum levels in patients with UA or with culprit vessel (CV) complexity score (CVCS), type of CV lesion, or vessel score in patients with UA or MI. These results suggest that CD40L plays a pathogenic role in triggering ACS.
Keywords:coronary artery disease / acute coronary syndrome / CD40 ligand / coronary angiogram
Source:Angiology, 2010, 61, 6, 567-573
- Research Center, Faculty of Medicine, Cairo University, Egypt, Ministry of Science, Republic of Serbia 
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