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dc.creatorTomic, Simonida L. J.
dc.creatorMićić, Maja M.
dc.creatorFilipović, Jovanka M.
dc.creatorSuljovrujić, Edin H.
dc.date.accessioned2018-03-01T21:15:45Z
dc.date.available2018-03-01T21:15:45Z
dc.date.issued2010
dc.identifier.issn1385-8947 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/4026
dc.description.abstractIn this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems. (C) 2010 Elsevier B.V. All rights reserved.en
dc.relationMinistry for Science and Technological Development of the Republic of Serbia [145072, 141013]
dc.rightsrestrictedAccessen
dc.sourceChemical Engineering Journalen
dc.subjectSmart hydrogelsen
dc.subjectEnvironmental sensitivityen
dc.subjectDrug releaseen
dc.subject2-Hydroxyethyl methacrylateen
dc.subjectPoly(alkylene glycol)(meth)acrylatesen
dc.titleSynthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogelsen
dc.typearticleen
dcterms.abstractШуљоврујић Един Х.; Томиц, Симонида Л. Ј.; Мициц, Маја М.; Филиповиц, Јованка М.;
dc.citation.volume160
dc.citation.issue2
dc.citation.spage801
dc.citation.epage809
dc.identifier.wos000279137900051
dc.identifier.doi10.1016/j.cej.2010.03.089
dc.citation.rankM21a
dc.identifier.scopus2-s2.0-77954815953


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