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dc.creatorĐorđević, Jelena D.
dc.creatorĐorđević, Ana D.
dc.creatorAdžić, Miroslav
dc.creatorRadoičić, Marija
dc.date.accessioned2018-03-01T21:15:14Z
dc.date.available2018-03-01T21:15:14Z
dc.date.issued2010
dc.identifier.issn0272-4340
dc.identifier.issn1573-6830
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/4020
dc.description.abstractChronic neuroendocrine stress usually leads to the elevation of the stress hormones and increased metabolic rate, which is frequently accompanied by oxidative damage to the CNS. In the present study we hypothesized that chronic psychosocial isolation (CPSI) of male Wistar rats, characterized by decreased serum corticosterone (CORT), unaltered catecholamines (CTs), and low blood glucose (GLU), may also promote oxidative imbalance in the CNS, by targeting antioxidant defense system. To test it, we have examined the relation between these input signals and protein expression/activity of antioxidant enzymes (AOEs): superoxide dismutases (SODs), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GLR) in the hippocampus (HIPPO) of CPSI animals. We found that CPSI did not affect SODs or CAT, but decreased activity of GPx and compromised GLR, an enzyme highly dependent on blood GLU for its substrate precursor. Further, we have tested whether the CPSI experience altered AOEs response to a novelty stress, and found that it attenuated peroxide-metabolizing enzymes, CAT and GPx, and decreased GLR activity, even though blood GLU was restored. The altered ratios of hippocampal AOEs in CPSI animals, which were worsened under the combined stress conditions, may lead to the accumulation of peroxide products and oxidative imbalance. The mechanism by which CPSI generate oxidative imbalance in the HIPPO is most likely based on poor systemic energy conditions set by this stress. Such conditions may cause functional decline of CNS structures, such as HIPPO, and are likely to promote state linked to onset of many mood disorders.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143042/RS//
dc.rightsrestrictedAccessen
dc.sourceCellular and Molecular Neurobiologyen
dc.subjectSocial isolationen
dc.subjectAntioxidant enzymesen
dc.subjectHippocampusen
dc.subjectCorticosteroneen
dc.subjectCatecholaminesen
dc.titleChronic Social Isolation Compromises the Activity of Both Glutathione Peroxidase and Catalase in Hippocampus of Male Wistar Ratsen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractЂорђевић Јелена Д.; Ђорђевић Aна Д; Aджић Мирослав; Радоичић Марија;
dc.citation.volume30
dc.citation.issue5
dc.citation.spage693
dc.citation.epage700
dc.identifier.wos000278937600006
dc.identifier.doi10.1007/s10571-009-9493-0
dc.citation.rankM23
dc.identifier.pmid20063054
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-77956267571


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