Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders
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Stanić, VojislavDimitrijević, Suzana I.
Antić-Stanković, Jelena
Mitrić, Miodrag
Jokić, Bojan M.
Plećaš, Ilija B.
Raičević, Slavica
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Antimicrobial materials based on hydroxyapatite are potentially attractive in a wide variety of medical applications. The synthesis of copper and zinc-doped hydroxyapatite was done by neutralization method. This method consists of dissolving CuO or ZnO in solution of H(3)PO(4), and the slow addition to suspension of Ca(OH)(2) for obtaining monophasic product. Characterization studies from XRD, SEM, TEM and FTIR spectra showed that particles of all samples are of nano size and they do not contain any discernible crystalline impurity. The quantitative elemental analysis showed that the copper and zinc ions fully incorporated into the hydroxyapatite. The antimicrobial effects of doped hydroxyapatite powders against pathogen bacterial strains Escherichia coli, Staphylococcus aureus and pathogen yeast Candida albicans were tested in solid and liquid media. Quantitative test in liquid media clearly showed that copper and zinc-doped samples had viable cells reduction ability for all tested st...rains. (C) 2010 Elsevier B. V. All rights reserved.
Keywords:
Hydroxyapatite / Cu / Zn / Nanoparticle / AntimicrobialSource:
Applied Surface Science, 2010, 256, 20, 6083-6089Funding / projects:
- Ministry of Science and Environmental Protection of the Republic of Serbia, [142050]
DOI: 10.1016/j.apsusc.2010.03.124
ISSN: 0169-4332
WoS: 000278530600051
Scopus: 2-s2.0-77953233019
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VinčaTY - JOUR AU - Stanić, Vojislav AU - Dimitrijević, Suzana I. AU - Antić-Stanković, Jelena AU - Mitrić, Miodrag AU - Jokić, Bojan M. AU - Plećaš, Ilija B. AU - Raičević, Slavica PY - 2010 UR - https://vinar.vin.bg.ac.rs/handle/123456789/4013 AB - Antimicrobial materials based on hydroxyapatite are potentially attractive in a wide variety of medical applications. The synthesis of copper and zinc-doped hydroxyapatite was done by neutralization method. This method consists of dissolving CuO or ZnO in solution of H(3)PO(4), and the slow addition to suspension of Ca(OH)(2) for obtaining monophasic product. Characterization studies from XRD, SEM, TEM and FTIR spectra showed that particles of all samples are of nano size and they do not contain any discernible crystalline impurity. The quantitative elemental analysis showed that the copper and zinc ions fully incorporated into the hydroxyapatite. The antimicrobial effects of doped hydroxyapatite powders against pathogen bacterial strains Escherichia coli, Staphylococcus aureus and pathogen yeast Candida albicans were tested in solid and liquid media. Quantitative test in liquid media clearly showed that copper and zinc-doped samples had viable cells reduction ability for all tested strains. (C) 2010 Elsevier B. V. All rights reserved. T2 - Applied Surface Science T1 - Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders VL - 256 IS - 20 SP - 6083 EP - 6089 DO - 10.1016/j.apsusc.2010.03.124 ER -
@article{ author = "Stanić, Vojislav and Dimitrijević, Suzana I. and Antić-Stanković, Jelena and Mitrić, Miodrag and Jokić, Bojan M. and Plećaš, Ilija B. and Raičević, Slavica", year = "2010", abstract = "Antimicrobial materials based on hydroxyapatite are potentially attractive in a wide variety of medical applications. The synthesis of copper and zinc-doped hydroxyapatite was done by neutralization method. This method consists of dissolving CuO or ZnO in solution of H(3)PO(4), and the slow addition to suspension of Ca(OH)(2) for obtaining monophasic product. Characterization studies from XRD, SEM, TEM and FTIR spectra showed that particles of all samples are of nano size and they do not contain any discernible crystalline impurity. The quantitative elemental analysis showed that the copper and zinc ions fully incorporated into the hydroxyapatite. The antimicrobial effects of doped hydroxyapatite powders against pathogen bacterial strains Escherichia coli, Staphylococcus aureus and pathogen yeast Candida albicans were tested in solid and liquid media. Quantitative test in liquid media clearly showed that copper and zinc-doped samples had viable cells reduction ability for all tested strains. (C) 2010 Elsevier B. V. All rights reserved.", journal = "Applied Surface Science", title = "Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders", volume = "256", number = "20", pages = "6083-6089", doi = "10.1016/j.apsusc.2010.03.124" }
Stanić, V., Dimitrijević, S. I., Antić-Stanković, J., Mitrić, M., Jokić, B. M., Plećaš, I. B.,& Raičević, S.. (2010). Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders. in Applied Surface Science, 256(20), 6083-6089. https://doi.org/10.1016/j.apsusc.2010.03.124
Stanić V, Dimitrijević SI, Antić-Stanković J, Mitrić M, Jokić BM, Plećaš IB, Raičević S. Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders. in Applied Surface Science. 2010;256(20):6083-6089. doi:10.1016/j.apsusc.2010.03.124 .
Stanić, Vojislav, Dimitrijević, Suzana I., Antić-Stanković, Jelena, Mitrić, Miodrag, Jokić, Bojan M., Plećaš, Ilija B., Raičević, Slavica, "Synthesis, characterization and antimicrobial activity of copper and zinc-doped hydroxyapatite nanopowders" in Applied Surface Science, 256, no. 20 (2010):6083-6089, https://doi.org/10.1016/j.apsusc.2010.03.124 . .