Non-Classical Therapeutic Approach in the Treatment of Alzheimers Disease: A Mini Review
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Bajić, Vladan P.Spremo-Potparević, Biljana
Živković, Lada
Sudar, Emina
Zafirović, Sonja
Obradović, Milan M.
Isenović, Esma R.
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Alzheimers disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.
Keywords:
Amyloid aggregation inhibitors / antioxidants / beta-sheet breakers / estrogens / immunotherapeutic Abeta / neurode-generationSource:
Letters in Drug Design and Discovery, 2015, 12, 2, 158-164Funding / projects:
- Hormonal regulation of expression and activity of the nitric oxide synthase and sodium-potassium pump in experimental models of insulin resistance, diabetes and cardiovascular disorders (RS-MESTD-Basic Research (BR or ON)-173033)
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
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VinčaTY - JOUR AU - Bajić, Vladan P. AU - Spremo-Potparević, Biljana AU - Živković, Lada AU - Sudar, Emina AU - Zafirović, Sonja AU - Obradović, Milan M. AU - Isenović, Esma R. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/398 AB - Alzheimers disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics. T2 - Letters in Drug Design and Discovery T1 - Non-Classical Therapeutic Approach in the Treatment of Alzheimers Disease: A Mini Review VL - 12 IS - 2 SP - 158 EP - 164 UR - https://hdl.handle.net/21.15107/rcub_vinar_398 ER -
@article{ author = "Bajić, Vladan P. and Spremo-Potparević, Biljana and Živković, Lada and Sudar, Emina and Zafirović, Sonja and Obradović, Milan M. and Isenović, Esma R.", year = "2015", abstract = "Alzheimers disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.", journal = "Letters in Drug Design and Discovery", title = "Non-Classical Therapeutic Approach in the Treatment of Alzheimers Disease: A Mini Review", volume = "12", number = "2", pages = "158-164", url = "https://hdl.handle.net/21.15107/rcub_vinar_398" }
Bajić, V. P., Spremo-Potparević, B., Živković, L., Sudar, E., Zafirović, S., Obradović, M. M.,& Isenović, E. R.. (2015). Non-Classical Therapeutic Approach in the Treatment of Alzheimers Disease: A Mini Review. in Letters in Drug Design and Discovery, 12(2), 158-164. https://hdl.handle.net/21.15107/rcub_vinar_398
Bajić VP, Spremo-Potparević B, Živković L, Sudar E, Zafirović S, Obradović MM, Isenović ER. Non-Classical Therapeutic Approach in the Treatment of Alzheimers Disease: A Mini Review. in Letters in Drug Design and Discovery. 2015;12(2):158-164. https://hdl.handle.net/21.15107/rcub_vinar_398 .
Bajić, Vladan P., Spremo-Potparević, Biljana, Živković, Lada, Sudar, Emina, Zafirović, Sonja, Obradović, Milan M., Isenović, Esma R., "Non-Classical Therapeutic Approach in the Treatment of Alzheimers Disease: A Mini Review" in Letters in Drug Design and Discovery, 12, no. 2 (2015):158-164, https://hdl.handle.net/21.15107/rcub_vinar_398 .