Приказ основних података о документу

dc.creatorTomić, Simonida Lj.
dc.creatorMićić, Maja M.
dc.creatorDobić, Sava N.
dc.creatorFilipović, Jovanka M.
dc.creatorSuljovrujić, Edin H.
dc.date.accessioned2018-03-01T21:10:10Z
dc.date.available2018-03-01T21:10:10Z
dc.date.issued2010
dc.identifier.issn0969-806X
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/3961
dc.description.abstractpH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. (C) 2009 Elsevier Ltd. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/141013/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145072/RS//
dc.rightsrestrictedAccessen
dc.sourceRadiation Physics and Chemistryen
dc.subjectgamma-radiationen
dc.subjectSmart hydrogelsen
dc.subject2-Hydroxyethyl methacrylateen
dc.subjectItaconic aciden
dc.subjectBiocompatibilityen
dc.subjectMicrobe penetrationen
dc.titleSmart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical applicationen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractТомиц, Симонида Љ; Шуљоврујић Един Х.; Добиц, Сава Н.; Филиповиц, Јованка М.; Мициц, Маја М.;
dc.citation.volume79
dc.citation.issue5
dc.citation.spage643
dc.citation.epage649
dc.identifier.wos000275997400014
dc.identifier.doi10.1016/j.radphyschem.2009.11.015
dc.citation.rankM21
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-76849096607


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Приказ основних података о документу