Приказ основних података о документу

dc.creatorBin-Jaliah, Ismaeel
dc.creatorAmmar, Hania I.
dc.creatorMikhailidis, Dimitri P.
dc.creatorDallak, Mohammed A.
dc.creatorAl-Hashem, Fahaid H.
dc.creatorHaidara, Mohamed A.
dc.creatorYassin, Hanaa Z.
dc.creatorBahnasi, Abeer A.
dc.creatorRashed, Laila A.
dc.creatorIsenović, Esma R.
dc.date.accessioned2018-03-01T21:03:29Z
dc.date.available2018-03-01T21:03:29Z
dc.date.issued2010
dc.identifier.issn0003-3197
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/3883
dc.description.abstractThe role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (Delta P/Delta t(max)) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P LT .001), RPP (P LT .001), and Delta P/Delta t(max) (P LT .001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms.en
dc.rightsrestrictedAccessen
dc.sourceAngiologyen
dc.subjectacute intermittent hypoxiaen
dc.subjecthypoxic preconditioningen
dc.subjectvascular endothelial growth factoren
dc.subjecterythropoietinen
dc.titleCardiac Adaptive Responses After Hypoxia in an Experimental Modelen
dc.typearticleen
dcterms.abstractБин-Јалиах, Исмаеел; Aммар, Ханиа И.; Микхаилидис, Димитри П.; Даллак, Мохаммед A.; Aл-Хасхем, Фахаид Х.; Хаидара, Мохамед A.; Yассин, Ханаа З.; Бахнаси, Aбеер A.; Расхед, Лаила A.; Исеновић Есма;
dc.citation.volume61
dc.citation.issue2
dc.citation.spage145
dc.citation.epage156
dc.identifier.wos000274024100004
dc.identifier.doi10.1177/0003319709352486
dc.citation.rankM23
dc.identifier.pmid19939823
dc.identifier.scopus2-s2.0-76649129859


Документи

ДатотекеВеличинаФорматПреглед

Уз овај запис нема датотека.

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу