The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats
Аутори
Adžić, MiroslavĐorđević, Ana D.
Demonacos, Constantinos
Krstić-Demonacos, Marija
Radojčić, Marija
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Mitochondrial dysfunction is increasingly recognized as a key component in compromised neuroendocrine stress response and. among other etiological causes. it may also involve action of glucocorticoid hormones. In the current study we followed glucocorticoid receptor and Identified its mitochondrial phosphoisophorms in hippocampus and prefrontal brain cortex of Wistar male rats subjected to acute. chronic and combined neuroendocrine stresses. In both brain structures chronic social isolation caused m,irked increase in mitochondrial glucocorticoid receptor that was preferentially phosphorylated at serine 232 compared to serine 246 or serine 171. This increase corresponded with the decreased expression of mitochondrially encoded cytochrome oxidase subunits 1 and 3 in hippocampus, and with their increased expression in prefrontal brain cortex. Prefrontal brain cortex appeared to be more sensitive to chronic stress, since it exibited higher levels of mitochondrial Bax and cytoplasmic Bcl2 c...ompared to hippocampus. Chronic stress also altered the response of both brain structures to subsequent acute stress according to the studied parameters. Therefore, prolonged social isolation may cause susceptibility to mitochondria triggered proapototic signalling. which at least in part may be mediated by the glucocorticoid receptor dependent mechanism. (C) 2009 Elsevier Ltd All rights reserved.
Кључне речи:
Glucocorticoid receptor / Phosphorylation / mitochondria / Hippocampus / Prefrontal cortexИзвор:
International Journal of Biochemistry and Cell Biology, 2009, 41, 11, 2181-2188Финансирање / пројекти:
- Ministry of Sciences of Serbia [143042B], Wellcome Trust [069024]
- Wellcome Trust [069024]
DOI: 10.1016/j.biocel.2009.04.001
ISSN: 1357-2725
PubMed: 19782950
WoS: 000271124700014
Scopus: 2-s2.0-70349381646
Колекције
Институција/група
VinčaTY - JOUR AU - Adžić, Miroslav AU - Đorđević, Ana D. AU - Demonacos, Constantinos AU - Krstić-Demonacos, Marija AU - Radojčić, Marija PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3810 AB - Mitochondrial dysfunction is increasingly recognized as a key component in compromised neuroendocrine stress response and. among other etiological causes. it may also involve action of glucocorticoid hormones. In the current study we followed glucocorticoid receptor and Identified its mitochondrial phosphoisophorms in hippocampus and prefrontal brain cortex of Wistar male rats subjected to acute. chronic and combined neuroendocrine stresses. In both brain structures chronic social isolation caused m,irked increase in mitochondrial glucocorticoid receptor that was preferentially phosphorylated at serine 232 compared to serine 246 or serine 171. This increase corresponded with the decreased expression of mitochondrially encoded cytochrome oxidase subunits 1 and 3 in hippocampus, and with their increased expression in prefrontal brain cortex. Prefrontal brain cortex appeared to be more sensitive to chronic stress, since it exibited higher levels of mitochondrial Bax and cytoplasmic Bcl2 compared to hippocampus. Chronic stress also altered the response of both brain structures to subsequent acute stress according to the studied parameters. Therefore, prolonged social isolation may cause susceptibility to mitochondria triggered proapototic signalling. which at least in part may be mediated by the glucocorticoid receptor dependent mechanism. (C) 2009 Elsevier Ltd All rights reserved. T2 - International Journal of Biochemistry and Cell Biology T1 - The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats VL - 41 IS - 11 SP - 2181 EP - 2188 DO - 10.1016/j.biocel.2009.04.001 ER -
@article{ author = "Adžić, Miroslav and Đorđević, Ana D. and Demonacos, Constantinos and Krstić-Demonacos, Marija and Radojčić, Marija", year = "2009", abstract = "Mitochondrial dysfunction is increasingly recognized as a key component in compromised neuroendocrine stress response and. among other etiological causes. it may also involve action of glucocorticoid hormones. In the current study we followed glucocorticoid receptor and Identified its mitochondrial phosphoisophorms in hippocampus and prefrontal brain cortex of Wistar male rats subjected to acute. chronic and combined neuroendocrine stresses. In both brain structures chronic social isolation caused m,irked increase in mitochondrial glucocorticoid receptor that was preferentially phosphorylated at serine 232 compared to serine 246 or serine 171. This increase corresponded with the decreased expression of mitochondrially encoded cytochrome oxidase subunits 1 and 3 in hippocampus, and with their increased expression in prefrontal brain cortex. Prefrontal brain cortex appeared to be more sensitive to chronic stress, since it exibited higher levels of mitochondrial Bax and cytoplasmic Bcl2 compared to hippocampus. Chronic stress also altered the response of both brain structures to subsequent acute stress according to the studied parameters. Therefore, prolonged social isolation may cause susceptibility to mitochondria triggered proapototic signalling. which at least in part may be mediated by the glucocorticoid receptor dependent mechanism. (C) 2009 Elsevier Ltd All rights reserved.", journal = "International Journal of Biochemistry and Cell Biology", title = "The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats", volume = "41", number = "11", pages = "2181-2188", doi = "10.1016/j.biocel.2009.04.001" }
Adžić, M., Đorđević, A. D., Demonacos, C., Krstić-Demonacos, M.,& Radojčić, M.. (2009). The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats. in International Journal of Biochemistry and Cell Biology, 41(11), 2181-2188. https://doi.org/10.1016/j.biocel.2009.04.001
Adžić M, Đorđević AD, Demonacos C, Krstić-Demonacos M, Radojčić M. The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats. in International Journal of Biochemistry and Cell Biology. 2009;41(11):2181-2188. doi:10.1016/j.biocel.2009.04.001 .
Adžić, Miroslav, Đorđević, Ana D., Demonacos, Constantinos, Krstić-Demonacos, Marija, Radojčić, Marija, "The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats" in International Journal of Biochemistry and Cell Biology, 41, no. 11 (2009):2181-2188, https://doi.org/10.1016/j.biocel.2009.04.001 . .