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dc.creatorBogdanović, Una
dc.creatorVodnik, Vesna
dc.creatorMitrić, Miodrag
dc.creatorDimitrijević, Suzana I.
dc.creatorŠkapin, Srečo Davor
dc.creatorZunic, Vojka
dc.creatorBudimir, Milica
dc.creatorStoiljković, Milovan
dc.date.accessioned2018-03-01T15:53:13Z
dc.date.available2018-03-01T15:53:13Z
dc.date.issued2015
dc.identifier.issn1944-8244 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/376
dc.description.abstractThis study explores different mechanisms of antimicrobial action by designing hybrid nanomaterials that provide a new approach in the fight against resistant microbes. Here, we present a cheap copper-polyaniline (Cu-PANI) nanocomposite material with enhanced antimicrobial properties, prepared by simple in situ polymerization method, when polymer and metal nanoparticles are produced simultaneously. The copper nanoparticles (CuNPs) are uniformly dispersed in the polymer and have a narrow size distribution (dav = 6 nm). We found that CuNPs and PANI act synergistically against three strains, Escherichia coli, Staphylococcus aureus, and Candida albicans, and resulting nanocomposite exhibits higher antimicrobial activity than any component acting alone. Before using the colony counting method to quantify its time and concentration antimicrobial activity, different techniques (UV-visible spectroscopy, transmission electron microscopy, scanning electron microscope, field emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrophotometry, and inductively coupled plasma optical emission spectrometry) were used to identify the optical, structural, and chemical aspects of the formed Cu-PANI nanocomposite. The antimicrobial activity of this nanocomposite shows that the microbial growth has been fully inhibited; moreover, some of the tested microbes were killed. Atomic force microscopy revealed dramatic changes in morphology of tested cells due to disruption of their cell wall integrity after incubation with Cu-PANI nanocomposite.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172056/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31035/RS//
dc.rightsrestrictedAccessen
dc.sourceACS Applied Materials and Interfacesen
dc.subjectcopper nanoparticlesen
dc.subjectpolyanilineen
dc.subjectnanocompositeen
dc.subjectantimicrobial activityen
dc.subjectAFMen
dc.titleNanomaterial with High Antimicrobial Efficacy-Copper/Polyaniline Nanocompositeen
dc.typearticleen
dcterms.abstractБудимир Милица; Водник Весна; Стоиљковић Милован; Митрић Миодраг; Богдановић Уна; Зуниц, Војка; Скапин, Срецо Д.; Димитријевиц, Сузана;
dc.citation.volume7
dc.citation.issue3
dc.citation.spage1955
dc.citation.epage1966
dc.identifier.wos000348688700070
dc.identifier.doi10.1021/am507746m
dc.citation.rankM21a
dc.identifier.pmid25552193
dc.identifier.scopus2-s2.0-84921813337


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