Nanomaterial with High Antimicrobial Efficacy-Copper/Polyaniline Nanocomposite
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Autori
Bogdanović, UnaVodnik, Vesna
Mitrić, Miodrag
Dimitrijević, Suzana I.
Škapin, Srečo Davor
Zunic, Vojka
Budimir, Milica
Stoiljković, Milovan
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This study explores different mechanisms of antimicrobial action by designing hybrid nanomaterials that provide a new approach in the fight against resistant microbes. Here, we present a cheap copper-polyaniline (Cu-PANI) nanocomposite material with enhanced antimicrobial properties, prepared by simple in situ polymerization method, when polymer and metal nanoparticles are produced simultaneously. The copper nanoparticles (CuNPs) are uniformly dispersed in the polymer and have a narrow size distribution (dav = 6 nm). We found that CuNPs and PANI act synergistically against three strains, Escherichia coli, Staphylococcus aureus, and Candida albicans, and resulting nanocomposite exhibits higher antimicrobial activity than any component acting alone. Before using the colony counting method to quantify its time and concentration antimicrobial activity, different techniques (UV-visible spectroscopy, transmission electron microscopy, scanning electron microscope, field emission scanning elec...tron microscopy, X-ray diffraction, Fourier transform infrared spectrophotometry, and inductively coupled plasma optical emission spectrometry) were used to identify the optical, structural, and chemical aspects of the formed Cu-PANI nanocomposite. The antimicrobial activity of this nanocomposite shows that the microbial growth has been fully inhibited; moreover, some of the tested microbes were killed. Atomic force microscopy revealed dramatic changes in morphology of tested cells due to disruption of their cell wall integrity after incubation with Cu-PANI nanocomposite.
Ključne reči:
copper nanoparticles / polyaniline / nanocomposite / antimicrobial activity / AFMIzvor:
ACS Applied Materials and Interfaces, 2015, 7, 3, 1955-1966Finansiranje / projekti:
- Uticaj veličine, oblika i strukture nanočestica na njihova svojstva i svojstva nanokompozita (RS-MESTD-Basic Research (BR or ON)-172056)
- Primena biotehnoloških metoda u održivom iskorišćenju nus-proizvoda agroindustrije (RS-MESTD-Technological Development (TD or TR)-31035)
DOI: 10.1021/am507746m
ISSN: 1944-8244
PubMed: 25552193
WoS: 000348688700070
Scopus: 2-s2.0-84921813337
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Bogdanović, Una AU - Vodnik, Vesna AU - Mitrić, Miodrag AU - Dimitrijević, Suzana I. AU - Škapin, Srečo Davor AU - Zunic, Vojka AU - Budimir, Milica AU - Stoiljković, Milovan PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/376 AB - This study explores different mechanisms of antimicrobial action by designing hybrid nanomaterials that provide a new approach in the fight against resistant microbes. Here, we present a cheap copper-polyaniline (Cu-PANI) nanocomposite material with enhanced antimicrobial properties, prepared by simple in situ polymerization method, when polymer and metal nanoparticles are produced simultaneously. The copper nanoparticles (CuNPs) are uniformly dispersed in the polymer and have a narrow size distribution (dav = 6 nm). We found that CuNPs and PANI act synergistically against three strains, Escherichia coli, Staphylococcus aureus, and Candida albicans, and resulting nanocomposite exhibits higher antimicrobial activity than any component acting alone. Before using the colony counting method to quantify its time and concentration antimicrobial activity, different techniques (UV-visible spectroscopy, transmission electron microscopy, scanning electron microscope, field emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrophotometry, and inductively coupled plasma optical emission spectrometry) were used to identify the optical, structural, and chemical aspects of the formed Cu-PANI nanocomposite. The antimicrobial activity of this nanocomposite shows that the microbial growth has been fully inhibited; moreover, some of the tested microbes were killed. Atomic force microscopy revealed dramatic changes in morphology of tested cells due to disruption of their cell wall integrity after incubation with Cu-PANI nanocomposite. T2 - ACS Applied Materials and Interfaces T1 - Nanomaterial with High Antimicrobial Efficacy-Copper/Polyaniline Nanocomposite VL - 7 IS - 3 SP - 1955 EP - 1966 DO - 10.1021/am507746m ER -
@article{ author = "Bogdanović, Una and Vodnik, Vesna and Mitrić, Miodrag and Dimitrijević, Suzana I. and Škapin, Srečo Davor and Zunic, Vojka and Budimir, Milica and Stoiljković, Milovan", year = "2015", abstract = "This study explores different mechanisms of antimicrobial action by designing hybrid nanomaterials that provide a new approach in the fight against resistant microbes. Here, we present a cheap copper-polyaniline (Cu-PANI) nanocomposite material with enhanced antimicrobial properties, prepared by simple in situ polymerization method, when polymer and metal nanoparticles are produced simultaneously. The copper nanoparticles (CuNPs) are uniformly dispersed in the polymer and have a narrow size distribution (dav = 6 nm). We found that CuNPs and PANI act synergistically against three strains, Escherichia coli, Staphylococcus aureus, and Candida albicans, and resulting nanocomposite exhibits higher antimicrobial activity than any component acting alone. Before using the colony counting method to quantify its time and concentration antimicrobial activity, different techniques (UV-visible spectroscopy, transmission electron microscopy, scanning electron microscope, field emission scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrophotometry, and inductively coupled plasma optical emission spectrometry) were used to identify the optical, structural, and chemical aspects of the formed Cu-PANI nanocomposite. The antimicrobial activity of this nanocomposite shows that the microbial growth has been fully inhibited; moreover, some of the tested microbes were killed. Atomic force microscopy revealed dramatic changes in morphology of tested cells due to disruption of their cell wall integrity after incubation with Cu-PANI nanocomposite.", journal = "ACS Applied Materials and Interfaces", title = "Nanomaterial with High Antimicrobial Efficacy-Copper/Polyaniline Nanocomposite", volume = "7", number = "3", pages = "1955-1966", doi = "10.1021/am507746m" }
Bogdanović, U., Vodnik, V., Mitrić, M., Dimitrijević, S. I., Škapin, S. D., Zunic, V., Budimir, M.,& Stoiljković, M.. (2015). Nanomaterial with High Antimicrobial Efficacy-Copper/Polyaniline Nanocomposite. in ACS Applied Materials and Interfaces, 7(3), 1955-1966. https://doi.org/10.1021/am507746m
Bogdanović U, Vodnik V, Mitrić M, Dimitrijević SI, Škapin SD, Zunic V, Budimir M, Stoiljković M. Nanomaterial with High Antimicrobial Efficacy-Copper/Polyaniline Nanocomposite. in ACS Applied Materials and Interfaces. 2015;7(3):1955-1966. doi:10.1021/am507746m .
Bogdanović, Una, Vodnik, Vesna, Mitrić, Miodrag, Dimitrijević, Suzana I., Škapin, Srečo Davor, Zunic, Vojka, Budimir, Milica, Stoiljković, Milovan, "Nanomaterial with High Antimicrobial Efficacy-Copper/Polyaniline Nanocomposite" in ACS Applied Materials and Interfaces, 7, no. 3 (2015):1955-1966, https://doi.org/10.1021/am507746m . .