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dc.creatorPetrovic, Snjezana
dc.creatorMilošević, Maja
dc.creatorStanojević, Ivana
dc.creatorVelickovic, Natasa
dc.creatorDrakulić, Dunja R.
dc.creatorHorvat, Anica
dc.date.accessioned2018-03-01T20:51:55Z
dc.date.available2018-03-01T20:51:55Z
dc.date.issued2009
dc.identifier.issn0354-4664 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/3749
dc.description.abstractThe role of membrane-bound estradiol in modulation of mitochondrial Ca2+ flux in nerve endings isolated from rat brain stem was examined. Physiological concentrations of 17 beta-estradiol bind specifically to isolated mitochondria (Bmax 33.8 +/- 2.5 fmoles estradiol/mg of protein, Km 0.185 +/- 0.006 nmoles/l free estradiol). At concentrations ranging from 1 x 10-10 to 2 x 10-9 moles/l, estradiol significantly (by 23-28%) decreases mitochondrial Na-dependent calcium efflux. Decreased calcium efflux was associated with increased affinity of the Na+/Ca2+ exchanger for Na+ and decreased capacity of the exchanger to extrude Ca2+. Calcium ion efflux modulation and mitochondrial ion retention may be the way that 17 beta-estradiol exerts its role in nerve cell homeostasis.en
dc.relationSerbian Ministry of Science [143044]
dc.rightsopenAccessen
dc.sourceArchives of biological sciencesen
dc.subjectmitochondriaen
dc.subjectestradiolen
dc.subjectCa2+ influxen
dc.subjectCa2+ effluxen
dc.titleInhibition of Mitochondrial Na-Dependent Ca2+ Efflux from Rat Brain Stem By 17 Beta-Estradiolen
dc.typearticleen
dcterms.abstractМилошевић Маја; Дракулић Дуња; Хорват, Aница; Петровиц, Сњезана; Станојевиц, Ивана; Велицковиц, Натаса;
dc.citation.volume61
dc.citation.issue2
dc.citation.spage171
dc.citation.epage177
dc.identifier.wos000268316000003
dc.identifier.doi10.2298/ABS0901171P
dc.citation.rankM23


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