Biological Effects of Echinacea Purpurea on Human Blood Cells
Abstract
The aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets b.i.d., according to a pharmacists recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation.
Keywords:
apoptosis / ionising radiation / micronuclei / protective effectsSource:
Arhiv za higijenu rada i toksikologiju, 2009, 60, 2, 165-172Funding / projects:
- Ministry of Science and Environmental Protection of Serbia [143046]
DOI: 10.2478/10004-1254-60-2009-1920
ISSN: 0004-1254; 1848-6312
PubMed: 19581209
WoS: 000267407500005
Scopus: 2-s2.0-67749110450
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Institution/Community
VinčaTY - JOUR AU - Joksić, Gordana AU - Petrović, Sandra AU - Joksić, Ivana AU - Leskovac, Andreja PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3728 AB - The aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets b.i.d., according to a pharmacists recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation. T2 - Arhiv za higijenu rada i toksikologiju T1 - Biological Effects of Echinacea Purpurea on Human Blood Cells VL - 60 IS - 2 SP - 165 EP - 172 DO - 10.2478/10004-1254-60-2009-1920 ER -
@article{ author = "Joksić, Gordana and Petrović, Sandra and Joksić, Ivana and Leskovac, Andreja", year = "2009", abstract = "The aim of this study was to investigate radioprotective properties of Echinacea purpurea tablets in vivo. We analysed lymphocyte chromosome aberrations (CA), micronuclei (MN), apoptosis of leukocytes and haematological parameters in a group of radiation workers who were identified as carrying dicentric chromosomes in their lymphocytes. All radiation workers were taking two 275 mg Echinacea tablets b.i.d., according to a pharmacists recommendation. All parameters were analysed before and after the two-week treatment. At the end of the treatment lymphocyte CA frequency dropped significantly, and the number of apoptotic cells increased. The inverse lymphocyte-to-granulocyte ratio at the beginning of the study changed to normal at its end. In conclusion, biological effects observed after administration of Echinacea purpurea preparation suggest that it may be beneficial for the prevention of adverse health effects in workers exposed to ionising radiation.", journal = "Arhiv za higijenu rada i toksikologiju", title = "Biological Effects of Echinacea Purpurea on Human Blood Cells", volume = "60", number = "2", pages = "165-172", doi = "10.2478/10004-1254-60-2009-1920" }
Joksić, G., Petrović, S., Joksić, I.,& Leskovac, A.. (2009). Biological Effects of Echinacea Purpurea on Human Blood Cells. in Arhiv za higijenu rada i toksikologiju, 60(2), 165-172. https://doi.org/10.2478/10004-1254-60-2009-1920
Joksić G, Petrović S, Joksić I, Leskovac A. Biological Effects of Echinacea Purpurea on Human Blood Cells. in Arhiv za higijenu rada i toksikologiju. 2009;60(2):165-172. doi:10.2478/10004-1254-60-2009-1920 .
Joksić, Gordana, Petrović, Sandra, Joksić, Ivana, Leskovac, Andreja, "Biological Effects of Echinacea Purpurea on Human Blood Cells" in Arhiv za higijenu rada i toksikologiju, 60, no. 2 (2009):165-172, https://doi.org/10.2478/10004-1254-60-2009-1920 . .