Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine
Аутори
Vasić, Dragana D.Savić, Jasmina
Bugaricic, Zivadin
Krstić, Danijela Z.
Tomić, Nenad
Čolović, Mirjana B.
Petković, Marijana
Vasić, Vesna M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The reaction between [PtCl,(DMSO)(2)] and L-cysteine (L-Cys) has been investigated in the presence of micelles of sodium dodecyl sulfate (SDS) - as a model for biological membranes. Additionally, the inhibitory effect of [PtCl2(DMSO)(2)] on the Na+,K+-ATPise activity and its partial prevention with 10 mM L-Cys were demonstrated. The interaction of L-Cys with [Ptcl(2)(DMSO)(2)] resulted in the formation of a [Pt(DMSO)(2)L-Cys)(2)](2+) (DMSO)(2)] Complex, which most probably occurs through stepwise replacement of Cl- with L-Cys. It has also been demonstrated that neither the pH value nor SDS affects the composition of the new complex. On the other hand, the pH value and SDS do affect the reaction rate, most probably due to electrostatic interactions with reactants. In Summary, this study can be used as a simple model approach for the investigation of reaction mechanisms between platinum complexes and various biomolecules, and for the determination of potential toxicity and/or side effect...s of antitumour platinum drugs.
Кључне речи:
Platinum Complexes / L-Cysteine / Na+,K+-ATPaseИзвор:
Zeitschrift fur Naturforschung. Section C: Journal of Biosciences, 2009, 64, 1-2, 103-108Финансирање / пројекти:
- Истраживање механизма интеракција биолошки активних једињења са биомолекулима (RS-MESTD-MPN2006-2010-142051)
DOI: 10.1515/znc-2009-1-217
ISSN: 0939-5075
PubMed: 19323274
WoS: 000264436900017
Scopus: 2-s2.0-62549094434
Колекције
Институција/група
VinčaTY - JOUR AU - Vasić, Dragana D. AU - Savić, Jasmina AU - Bugaricic, Zivadin AU - Krstić, Danijela Z. AU - Tomić, Nenad AU - Čolović, Mirjana B. AU - Petković, Marijana AU - Vasić, Vesna M. PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3657 AB - The reaction between [PtCl,(DMSO)(2)] and L-cysteine (L-Cys) has been investigated in the presence of micelles of sodium dodecyl sulfate (SDS) - as a model for biological membranes. Additionally, the inhibitory effect of [PtCl2(DMSO)(2)] on the Na+,K+-ATPise activity and its partial prevention with 10 mM L-Cys were demonstrated. The interaction of L-Cys with [Ptcl(2)(DMSO)(2)] resulted in the formation of a [Pt(DMSO)(2)L-Cys)(2)](2+) (DMSO)(2)] Complex, which most probably occurs through stepwise replacement of Cl- with L-Cys. It has also been demonstrated that neither the pH value nor SDS affects the composition of the new complex. On the other hand, the pH value and SDS do affect the reaction rate, most probably due to electrostatic interactions with reactants. In Summary, this study can be used as a simple model approach for the investigation of reaction mechanisms between platinum complexes and various biomolecules, and for the determination of potential toxicity and/or side effects of antitumour platinum drugs. T2 - Zeitschrift fur Naturforschung. Section C: Journal of Biosciences T1 - Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine VL - 64 IS - 1-2 SP - 103 EP - 108 DO - 10.1515/znc-2009-1-217 UR - https://hdl.handle.net/21.15107/rcub_vinar_3657 ER -
@article{ author = "Vasić, Dragana D. and Savić, Jasmina and Bugaricic, Zivadin and Krstić, Danijela Z. and Tomić, Nenad and Čolović, Mirjana B. and Petković, Marijana and Vasić, Vesna M.", year = "2009", abstract = "The reaction between [PtCl,(DMSO)(2)] and L-cysteine (L-Cys) has been investigated in the presence of micelles of sodium dodecyl sulfate (SDS) - as a model for biological membranes. Additionally, the inhibitory effect of [PtCl2(DMSO)(2)] on the Na+,K+-ATPise activity and its partial prevention with 10 mM L-Cys were demonstrated. The interaction of L-Cys with [Ptcl(2)(DMSO)(2)] resulted in the formation of a [Pt(DMSO)(2)L-Cys)(2)](2+) (DMSO)(2)] Complex, which most probably occurs through stepwise replacement of Cl- with L-Cys. It has also been demonstrated that neither the pH value nor SDS affects the composition of the new complex. On the other hand, the pH value and SDS do affect the reaction rate, most probably due to electrostatic interactions with reactants. In Summary, this study can be used as a simple model approach for the investigation of reaction mechanisms between platinum complexes and various biomolecules, and for the determination of potential toxicity and/or side effects of antitumour platinum drugs.", journal = "Zeitschrift fur Naturforschung. Section C: Journal of Biosciences", title = "Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine", volume = "64", number = "1-2", pages = "103-108", doi = "10.1515/znc-2009-1-217", url = "https://hdl.handle.net/21.15107/rcub_vinar_3657" }
Vasić, D. D., Savić, J., Bugaricic, Z., Krstić, D. Z., Tomić, N., Čolović, M. B., Petković, M.,& Vasić, V. M.. (2009). Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine. in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences, 64(1-2), 103-108. https://doi.org/10.1515/znc-2009-1-217 https://hdl.handle.net/21.15107/rcub_vinar_3657
Vasić DD, Savić J, Bugaricic Z, Krstić DZ, Tomić N, Čolović MB, Petković M, Vasić VM. Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine. in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences. 2009;64(1-2):103-108. doi:10.1515/znc-2009-1-217 https://hdl.handle.net/21.15107/rcub_vinar_3657 .
Vasić, Dragana D., Savić, Jasmina, Bugaricic, Zivadin, Krstić, Danijela Z., Tomić, Nenad, Čolović, Mirjana B., Petković, Marijana, Vasić, Vesna M., "Interaction of the [PtCl2(DMSO)(2)] Complex with L-Cysteine" in Zeitschrift fur Naturforschung. Section C: Journal of Biosciences, 64, no. 1-2 (2009):103-108, https://doi.org/10.1515/znc-2009-1-217 ., https://hdl.handle.net/21.15107/rcub_vinar_3657 .