Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats
Apstrakt
Influence of previous stress exposure on the effects of serotonergic and noradrenergic antidepressants on subsequent newly induced stress is still far from being completely understood. The aim of the present study was to investigate changes in the activity of the sympatho-adrenomedullary system in unstressed and chronic unpredictable mild stressed (CUMS) rats treated with either maprotiline or fluxilan, both under basal conditions and subsequent immobilization stress. Maprotiline and fluxilan elevated plasma norepinephrine in unstressed control and CUMS rats. Immobilization increased norepinephrine less in unstressed maprotiline- or fluxilan controls than in vehicle group. Subsequent immobilization elevated norepinephrine in CUMS rats the differences between the groups being insignificant. Maprotiline didnt affect epinephrine in unstressed and CUMS rats and fluxilan increased it. Subsequent immobilization elevated epinephrine in unstressed maprotiline controls less than in vehicle anim...als. Epinephrine increase was similar in maprotiline CUMS and vehicle CUMS rats. Immobilization of fluxilan unstressed and CUMS rats significantly increased epinephrine but without differences compared to vehicle group. Novel stressor activated sympatho-adrenomedullary system of CUMS rats upon antidepressants. (c) 2008 Elsevier B.V. All rights reserved.
Ključne reči:
Stress / Antidepressant / Norepinephrine / Epinephrine / ImmobilizationIzvor:
Autonomic Neuroscience: Basic and Clinical, 2009, 145, 1-2, 104-107Finansiranje / projekti:
- Ministry for Science, Technology and Environmental Protection of the Republic of Serbia [143 044B]
DOI: 10.1016/j.autneu.2008.11.002
ISSN: 1566-0702
PubMed: 19083273
WoS: 000263191400016
Scopus: 2-s2.0-58149512868
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Spasojević, Nataša AU - Gavrilović, Ljubica AU - Kovacevic, Ivan AU - Dronjak, Slađana PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3633 AB - Influence of previous stress exposure on the effects of serotonergic and noradrenergic antidepressants on subsequent newly induced stress is still far from being completely understood. The aim of the present study was to investigate changes in the activity of the sympatho-adrenomedullary system in unstressed and chronic unpredictable mild stressed (CUMS) rats treated with either maprotiline or fluxilan, both under basal conditions and subsequent immobilization stress. Maprotiline and fluxilan elevated plasma norepinephrine in unstressed control and CUMS rats. Immobilization increased norepinephrine less in unstressed maprotiline- or fluxilan controls than in vehicle group. Subsequent immobilization elevated norepinephrine in CUMS rats the differences between the groups being insignificant. Maprotiline didnt affect epinephrine in unstressed and CUMS rats and fluxilan increased it. Subsequent immobilization elevated epinephrine in unstressed maprotiline controls less than in vehicle animals. Epinephrine increase was similar in maprotiline CUMS and vehicle CUMS rats. Immobilization of fluxilan unstressed and CUMS rats significantly increased epinephrine but without differences compared to vehicle group. Novel stressor activated sympatho-adrenomedullary system of CUMS rats upon antidepressants. (c) 2008 Elsevier B.V. All rights reserved. T2 - Autonomic Neuroscience: Basic and Clinical T1 - Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats VL - 145 IS - 1-2 SP - 104 EP - 107 DO - 10.1016/j.autneu.2008.11.002 ER -
@article{ author = "Spasojević, Nataša and Gavrilović, Ljubica and Kovacevic, Ivan and Dronjak, Slađana", year = "2009", abstract = "Influence of previous stress exposure on the effects of serotonergic and noradrenergic antidepressants on subsequent newly induced stress is still far from being completely understood. The aim of the present study was to investigate changes in the activity of the sympatho-adrenomedullary system in unstressed and chronic unpredictable mild stressed (CUMS) rats treated with either maprotiline or fluxilan, both under basal conditions and subsequent immobilization stress. Maprotiline and fluxilan elevated plasma norepinephrine in unstressed control and CUMS rats. Immobilization increased norepinephrine less in unstressed maprotiline- or fluxilan controls than in vehicle group. Subsequent immobilization elevated norepinephrine in CUMS rats the differences between the groups being insignificant. Maprotiline didnt affect epinephrine in unstressed and CUMS rats and fluxilan increased it. Subsequent immobilization elevated epinephrine in unstressed maprotiline controls less than in vehicle animals. Epinephrine increase was similar in maprotiline CUMS and vehicle CUMS rats. Immobilization of fluxilan unstressed and CUMS rats significantly increased epinephrine but without differences compared to vehicle group. Novel stressor activated sympatho-adrenomedullary system of CUMS rats upon antidepressants. (c) 2008 Elsevier B.V. All rights reserved.", journal = "Autonomic Neuroscience: Basic and Clinical", title = "Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats", volume = "145", number = "1-2", pages = "104-107", doi = "10.1016/j.autneu.2008.11.002" }
Spasojević, N., Gavrilović, L., Kovacevic, I.,& Dronjak, S.. (2009). Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats. in Autonomic Neuroscience: Basic and Clinical, 145(1-2), 104-107. https://doi.org/10.1016/j.autneu.2008.11.002
Spasojević N, Gavrilović L, Kovacevic I, Dronjak S. Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats. in Autonomic Neuroscience: Basic and Clinical. 2009;145(1-2):104-107. doi:10.1016/j.autneu.2008.11.002 .
Spasojević, Nataša, Gavrilović, Ljubica, Kovacevic, Ivan, Dronjak, Slađana, "Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats" in Autonomic Neuroscience: Basic and Clinical, 145, no. 1-2 (2009):104-107, https://doi.org/10.1016/j.autneu.2008.11.002 . .