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dc.creatorTodorović, Danijela V.
dc.creatorPetrović, Ivan M.
dc.creatorTodorovic, M.
dc.creatorCuttone, Giacomo
dc.creatorRistić-Fira, Aleksandra
dc.date.accessioned2018-03-01T20:36:35Z
dc.date.available2018-03-01T20:36:35Z
dc.date.issued2008
dc.identifier.issn0022-2720 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/3573
dc.description.abstractThe effects of irradiation with gamma rays and protons on HTB140 human melanoma cell morphology and viability were analyzed. Exponentially growing cells were irradiated close to the Bragg peak maximum of the 62-MeV proton beam, as well as with (60)Co gamma rays, with doses ranging from 8 to 24 Gy. The overall cell morphology was unchanged 6 and 48 h after gamma irradiation, also showing a relatively weak cell-inactivation level. After exposure to proton beam, considerable changes in cell morphology followed by stronger cell inactivation were achieved. Proliferation capacity of irradiated cells significantly decreased in both experimental set-ups. Higher ionization level of protons with respect to gamma rays, representing the main physical difference between these two types of radiation, was also revealed on the cell membrane level through larger pro-apoptotic capacity of protons.en
dc.rightsopenAccessen
dc.sourceJournal of Microscopy, Oxforden
dc.subjectApoptosisen
dc.subjectcell morphologyen
dc.subjectgamma raysen
dc.subjectmelanoma cellsen
dc.subjectproliferationen
dc.subjectprotonsen
dc.titleEarly effects of gamma rays and protons on human melanoma cell viability and morphologyen
dc.typearticleen
dcterms.abstractТодоровиц, Д.; Тодоровиц, М.; Петровић Иван; Цуттоне, Г.; Ристић-Фира Aлександра;
dc.citation.volume232
dc.citation.issue3
dc.citation.spage517
dc.citation.epage521
dc.identifier.wos000261253200018
dc.identifier.doi10.1111/j.1365-2818.2008.02151.x
dc.citation.rankM23
dc.identifier.pmid19094032
dc.identifier.scopus2-s2.0-57449121824
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/4832/j.1365-2818.2008.02151.x.pdf


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