Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis
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Đurić, TamaraŽivković, Maja
Radak, Đorđe J.
Jekić, Đole
Radak, Sandra
Stojković, Ljiljana S.
Raičević, Ranko
Stanković, Aleksandra
Alavantić, Dragan
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Objectives: Stromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low-and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population. Design and methods: The study group of case-control design consisted of 515 participants. The 265 patients with ultrasonographic evidence of carotid plaque presence were recruited for the study. The 5A/6A polymorphism was typed by RFLP-PCR. Results: There was significantly higher prevalence of genotypes containing 6A allele in the patients with CA compared to controls (p LT 0.05). The model of inheritance with the dominant effect of 6A allele gave elevated and significant OR for carotid atherosclerosis (adjusted OR 2.35, CI = 1.0-5.5, p=0.048). Conclusions: Subjects carrying genotypes with 6A allele had significan...tly higher susceptibility to carotid atherosclerosis. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Keywords:
MMP-3 / 5A/6A / Gene polymorphism / Carotid atherosclerosis / HumanSource:
Clinical Biochemistry, 2008, 41, 16-17, 1326-1329Funding / projects:
- Serbian Government Research Grant [M145023]
DOI: 10.1016/j.clinbiochem.2008.08.081
ISSN: 0009-9120
PubMed: 18801353
WoS: 000260934300004
Scopus: 2-s2.0-55149085663
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VinčaTY - JOUR AU - Đurić, Tamara AU - Živković, Maja AU - Radak, Đorđe J. AU - Jekić, Đole AU - Radak, Sandra AU - Stojković, Ljiljana S. AU - Raičević, Ranko AU - Stanković, Aleksandra AU - Alavantić, Dragan PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3571 AB - Objectives: Stromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low-and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population. Design and methods: The study group of case-control design consisted of 515 participants. The 265 patients with ultrasonographic evidence of carotid plaque presence were recruited for the study. The 5A/6A polymorphism was typed by RFLP-PCR. Results: There was significantly higher prevalence of genotypes containing 6A allele in the patients with CA compared to controls (p LT 0.05). The model of inheritance with the dominant effect of 6A allele gave elevated and significant OR for carotid atherosclerosis (adjusted OR 2.35, CI = 1.0-5.5, p=0.048). Conclusions: Subjects carrying genotypes with 6A allele had significantly higher susceptibility to carotid atherosclerosis. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. T2 - Clinical Biochemistry T1 - Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis VL - 41 IS - 16-17 SP - 1326 EP - 1329 DO - 10.1016/j.clinbiochem.2008.08.081 ER -
@article{ author = "Đurić, Tamara and Živković, Maja and Radak, Đorđe J. and Jekić, Đole and Radak, Sandra and Stojković, Ljiljana S. and Raičević, Ranko and Stanković, Aleksandra and Alavantić, Dragan", year = "2008", abstract = "Objectives: Stromelysin-1 (MMP-3) as a key member of metalloproteinase family could have an important role in atherogenesis. The 5A/6A polymorphism in the promoter of MMP-3 gene affects the level of MMP-3 gene expression. We assessed whether the MMP-3 promoter low-and high-activity genotypes are related to susceptibility for carotid atherosclerosis (CA) in Serbian population. Design and methods: The study group of case-control design consisted of 515 participants. The 265 patients with ultrasonographic evidence of carotid plaque presence were recruited for the study. The 5A/6A polymorphism was typed by RFLP-PCR. Results: There was significantly higher prevalence of genotypes containing 6A allele in the patients with CA compared to controls (p LT 0.05). The model of inheritance with the dominant effect of 6A allele gave elevated and significant OR for carotid atherosclerosis (adjusted OR 2.35, CI = 1.0-5.5, p=0.048). Conclusions: Subjects carrying genotypes with 6A allele had significantly higher susceptibility to carotid atherosclerosis. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.", journal = "Clinical Biochemistry", title = "Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis", volume = "41", number = "16-17", pages = "1326-1329", doi = "10.1016/j.clinbiochem.2008.08.081" }
Đurić, T., Živković, M., Radak, Đ. J., Jekić, Đ., Radak, S., Stojković, L. S., Raičević, R., Stanković, A.,& Alavantić, D.. (2008). Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis. in Clinical Biochemistry, 41(16-17), 1326-1329. https://doi.org/10.1016/j.clinbiochem.2008.08.081
Đurić T, Živković M, Radak ĐJ, Jekić Đ, Radak S, Stojković LS, Raičević R, Stanković A, Alavantić D. Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis. in Clinical Biochemistry. 2008;41(16-17):1326-1329. doi:10.1016/j.clinbiochem.2008.08.081 .
Đurić, Tamara, Živković, Maja, Radak, Đorđe J., Jekić, Đole, Radak, Sandra, Stojković, Ljiljana S., Raičević, Ranko, Stanković, Aleksandra, Alavantić, Dragan, "Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis" in Clinical Biochemistry, 41, no. 16-17 (2008):1326-1329, https://doi.org/10.1016/j.clinbiochem.2008.08.081 . .