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Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro
dc.creator | Petrović, Sandra | |
dc.creator | Leskovac, Andreja | |
dc.creator | Joksić, Gordana | |
dc.date.accessioned | 2018-03-01T20:36:05Z | |
dc.date.available | 2018-03-01T20:36:05Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0011-3891 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3567 | |
dc.description.abstract | The radioprotective properties of polyphenols from the plant Gentiana dinarica Beck. (family Gentianaceae) were evaluated in cultured human peripheral blood lymphocytes exposed to 2 Gy of gamma radiation in vitro. Major constituents of G. dinarica roots include tetraoxygenated xanthones (gentiacaulein and gentiakochianin), tetraoxygenated xanthone glycosides (norswertianin- 1-O-primveroside and norswertianin-8-O-primveroside), C-glucoflavones (isoorientin and isoorientin- 4-O-glycoside) and secoridoids. The incidences of micronuclei, cell proliferation, apoptosis and lipid peroxidation products were examined. Isoorientin, isoorientin- 4-O-glycoside and norswertianin-1-O-primveroside showed antioxidant properties, whereas norswertianin-8-O-primveroside and gentiacaulein exhibited pro-oxidative effects. Gentiakochianin exhibited cytostatic effects in irradiated lymphocytes. These results contribute to the search for novel radioprotective agents. | en |
dc.relation | Serbian Ministry of Science and Environmental Protection [143046] | |
dc.rights | openAccess | en |
dc.source | Current Science | en |
dc.subject | Gentiana dinarica | en |
dc.subject | human lymphocytes | en |
dc.subject | polyphenols | en |
dc.subject | radioprotection | en |
dc.title | Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro | en |
dc.type | article | en |
dcterms.abstract | Петровић, Сандра; Лесковац Aндреја; Јоксић Гордана; | |
dc.citation.volume | 95 | |
dc.citation.issue | 8 | |
dc.citation.spage | 1035 | |
dc.citation.epage | 1041 | |
dc.identifier.wos | 000260871800019 | |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_vinar_3567 |
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