Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro
Abstract
The radioprotective properties of polyphenols from the plant Gentiana dinarica Beck. (family Gentianaceae) were evaluated in cultured human peripheral blood lymphocytes exposed to 2 Gy of gamma radiation in vitro. Major constituents of G. dinarica roots include tetraoxygenated xanthones (gentiacaulein and gentiakochianin), tetraoxygenated xanthone glycosides (norswertianin- 1-O-primveroside and norswertianin-8-O-primveroside), C-glucoflavones (isoorientin and isoorientin- 4-O-glycoside) and secoridoids. The incidences of micronuclei, cell proliferation, apoptosis and lipid peroxidation products were examined. Isoorientin, isoorientin- 4-O-glycoside and norswertianin-1-O-primveroside showed antioxidant properties, whereas norswertianin-8-O-primveroside and gentiacaulein exhibited pro-oxidative effects. Gentiakochianin exhibited cytostatic effects in irradiated lymphocytes. These results contribute to the search for novel radioprotective agents.
Keywords:
Gentiana dinarica / human lymphocytes / polyphenols / radioprotectionSource:
Current Science, 2008, 95, 8, 1035-1041Funding / projects:
- Serbian Ministry of Science and Environmental Protection [143046]
Collections
Institution/Community
VinčaTY - JOUR AU - Petrović, Sandra AU - Leskovac, Andreja AU - Joksić, Gordana PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3567 AB - The radioprotective properties of polyphenols from the plant Gentiana dinarica Beck. (family Gentianaceae) were evaluated in cultured human peripheral blood lymphocytes exposed to 2 Gy of gamma radiation in vitro. Major constituents of G. dinarica roots include tetraoxygenated xanthones (gentiacaulein and gentiakochianin), tetraoxygenated xanthone glycosides (norswertianin- 1-O-primveroside and norswertianin-8-O-primveroside), C-glucoflavones (isoorientin and isoorientin- 4-O-glycoside) and secoridoids. The incidences of micronuclei, cell proliferation, apoptosis and lipid peroxidation products were examined. Isoorientin, isoorientin- 4-O-glycoside and norswertianin-1-O-primveroside showed antioxidant properties, whereas norswertianin-8-O-primveroside and gentiacaulein exhibited pro-oxidative effects. Gentiakochianin exhibited cytostatic effects in irradiated lymphocytes. These results contribute to the search for novel radioprotective agents. T2 - Current Science T1 - Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro VL - 95 IS - 8 SP - 1035 EP - 1041 UR - https://hdl.handle.net/21.15107/rcub_vinar_3567 ER -
@article{ author = "Petrović, Sandra and Leskovac, Andreja and Joksić, Gordana", year = "2008", abstract = "The radioprotective properties of polyphenols from the plant Gentiana dinarica Beck. (family Gentianaceae) were evaluated in cultured human peripheral blood lymphocytes exposed to 2 Gy of gamma radiation in vitro. Major constituents of G. dinarica roots include tetraoxygenated xanthones (gentiacaulein and gentiakochianin), tetraoxygenated xanthone glycosides (norswertianin- 1-O-primveroside and norswertianin-8-O-primveroside), C-glucoflavones (isoorientin and isoorientin- 4-O-glycoside) and secoridoids. The incidences of micronuclei, cell proliferation, apoptosis and lipid peroxidation products were examined. Isoorientin, isoorientin- 4-O-glycoside and norswertianin-1-O-primveroside showed antioxidant properties, whereas norswertianin-8-O-primveroside and gentiacaulein exhibited pro-oxidative effects. Gentiakochianin exhibited cytostatic effects in irradiated lymphocytes. These results contribute to the search for novel radioprotective agents.", journal = "Current Science", title = "Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro", volume = "95", number = "8", pages = "1035-1041", url = "https://hdl.handle.net/21.15107/rcub_vinar_3567" }
Petrović, S., Leskovac, A.,& Joksić, G.. (2008). Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro. in Current Science, 95(8), 1035-1041. https://hdl.handle.net/21.15107/rcub_vinar_3567
Petrović S, Leskovac A, Joksić G. Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro. in Current Science. 2008;95(8):1035-1041. https://hdl.handle.net/21.15107/rcub_vinar_3567 .
Petrović, Sandra, Leskovac, Andreja, Joksić, Gordana, "Radioprotective properties of Gentiana dinarica polyphenols on human lymphocytes in vitro" in Current Science, 95, no. 8 (2008):1035-1041, https://hdl.handle.net/21.15107/rcub_vinar_3567 .