Discovery of New Therapeutic Targets by the Informational Spectrum Method
AuthorsVeljković, Nevena V.
Perović, Vladimir R.
MetadataShow full item record
The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method ( ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases.
Keywords:Bioinformatics / target / electron-ion interaction potential / informational spectrum method / H5N1 / HIV-1 / anthrax
Source:Current Protein and Peptide Science, 2008, 9, 5, 493-506
- Ministry of Science of the Republic of Serbia