Smart poly(oligo(propylene glycol) methacrylate) hydrogel prepared by gamma radiation
Апстракт
The synthesis of poly(oligo(propylene glycol) methacrylate) (POPGMA) from functionalised oligo(propylene glycol) methacrylate (OPGMA) monomers by gamma radiation-induced radical polymerisation is reported for the first time; POPGMA homopolymeric hydrogel with oligo(propylene glycol) (OPG) pendant chains, as a non-linear PPGMA-analogue, was synthesised from an monomer-solvent (OPGMA(375)-water/ethanol) mixture at different irradiation doses (5, 10, 25, and 40 kGy). Determination of the gel fraction was conducted after synthesis. The swelling properties of the POPGMA hydrogel were preliminarily investigated over wide pH (2.2-9.0) and temperature (4-70 degrees C) ranges. Additional characterisation of structure and properties was conducted by UV-vis and Fourier transform infrared (FTIR) spectroscopy as well as by differential scanning calorimetry (DSC). In order to evaluate the potential for biomedical applications, biocompatibility (cytocompatibility and haemolytic activity) studies were... performed as well. Sol-gel conversion was relatively high for all irradiation doses, indicating radiation-induced synthesis as a good method for fabricating this hydrogel. Thermoresponsiveness and variations in swelling capacity as a result of thermosensitive OPG pendant chains with a lower critical solution temperature (LCST) were mainly observed below room temperature; thus, the volume phase transition temperature (VPTT) of POPGMA homopolymeric hydrogel is about 15 degrees C. Furthermore, POPGMA has satisfactory biocompatibility. The results indicate that the hydrogels with propylene glycol pendant chains can be easily prepared by gamma radiation and have potential for different applications as smart and biocompatible polymers. (C) 2014 Elsevier B.V. All rights reserved.
Кључне речи:
Radiation synthesis / Poly(propylene glycol) methacrylate / Thermoresponsive hydrogel / LCSTИзвор:
Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 2015, 342, 206-214Финансирање / пројекти:
- Хемијско и структурно дизајнирање наноматеријала за примену у медицини и инжењерству ткива (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.1016/j.nimb.2014.10.008
ISSN: 0168-583X; 1872-9584
WoS: 000347770500032
Scopus: 2-s2.0-84908374100
Колекције
Институција/група
VinčaTY - JOUR AU - Suljovrujić, Edin H. AU - Mićić, Maja M. PY - 2015 UR - https://vinar.vin.bg.ac.rs/handle/123456789/353 AB - The synthesis of poly(oligo(propylene glycol) methacrylate) (POPGMA) from functionalised oligo(propylene glycol) methacrylate (OPGMA) monomers by gamma radiation-induced radical polymerisation is reported for the first time; POPGMA homopolymeric hydrogel with oligo(propylene glycol) (OPG) pendant chains, as a non-linear PPGMA-analogue, was synthesised from an monomer-solvent (OPGMA(375)-water/ethanol) mixture at different irradiation doses (5, 10, 25, and 40 kGy). Determination of the gel fraction was conducted after synthesis. The swelling properties of the POPGMA hydrogel were preliminarily investigated over wide pH (2.2-9.0) and temperature (4-70 degrees C) ranges. Additional characterisation of structure and properties was conducted by UV-vis and Fourier transform infrared (FTIR) spectroscopy as well as by differential scanning calorimetry (DSC). In order to evaluate the potential for biomedical applications, biocompatibility (cytocompatibility and haemolytic activity) studies were performed as well. Sol-gel conversion was relatively high for all irradiation doses, indicating radiation-induced synthesis as a good method for fabricating this hydrogel. Thermoresponsiveness and variations in swelling capacity as a result of thermosensitive OPG pendant chains with a lower critical solution temperature (LCST) were mainly observed below room temperature; thus, the volume phase transition temperature (VPTT) of POPGMA homopolymeric hydrogel is about 15 degrees C. Furthermore, POPGMA has satisfactory biocompatibility. The results indicate that the hydrogels with propylene glycol pendant chains can be easily prepared by gamma radiation and have potential for different applications as smart and biocompatible polymers. (C) 2014 Elsevier B.V. All rights reserved. T2 - Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms T1 - Smart poly(oligo(propylene glycol) methacrylate) hydrogel prepared by gamma radiation VL - 342 SP - 206 EP - 214 DO - 10.1016/j.nimb.2014.10.008 ER -
@article{ author = "Suljovrujić, Edin H. and Mićić, Maja M.", year = "2015", abstract = "The synthesis of poly(oligo(propylene glycol) methacrylate) (POPGMA) from functionalised oligo(propylene glycol) methacrylate (OPGMA) monomers by gamma radiation-induced radical polymerisation is reported for the first time; POPGMA homopolymeric hydrogel with oligo(propylene glycol) (OPG) pendant chains, as a non-linear PPGMA-analogue, was synthesised from an monomer-solvent (OPGMA(375)-water/ethanol) mixture at different irradiation doses (5, 10, 25, and 40 kGy). Determination of the gel fraction was conducted after synthesis. The swelling properties of the POPGMA hydrogel were preliminarily investigated over wide pH (2.2-9.0) and temperature (4-70 degrees C) ranges. Additional characterisation of structure and properties was conducted by UV-vis and Fourier transform infrared (FTIR) spectroscopy as well as by differential scanning calorimetry (DSC). In order to evaluate the potential for biomedical applications, biocompatibility (cytocompatibility and haemolytic activity) studies were performed as well. Sol-gel conversion was relatively high for all irradiation doses, indicating radiation-induced synthesis as a good method for fabricating this hydrogel. Thermoresponsiveness and variations in swelling capacity as a result of thermosensitive OPG pendant chains with a lower critical solution temperature (LCST) were mainly observed below room temperature; thus, the volume phase transition temperature (VPTT) of POPGMA homopolymeric hydrogel is about 15 degrees C. Furthermore, POPGMA has satisfactory biocompatibility. The results indicate that the hydrogels with propylene glycol pendant chains can be easily prepared by gamma radiation and have potential for different applications as smart and biocompatible polymers. (C) 2014 Elsevier B.V. All rights reserved.", journal = "Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms", title = "Smart poly(oligo(propylene glycol) methacrylate) hydrogel prepared by gamma radiation", volume = "342", pages = "206-214", doi = "10.1016/j.nimb.2014.10.008" }
Suljovrujić, E. H.,& Mićić, M. M.. (2015). Smart poly(oligo(propylene glycol) methacrylate) hydrogel prepared by gamma radiation. in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 342, 206-214. https://doi.org/10.1016/j.nimb.2014.10.008
Suljovrujić EH, Mićić MM. Smart poly(oligo(propylene glycol) methacrylate) hydrogel prepared by gamma radiation. in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms. 2015;342:206-214. doi:10.1016/j.nimb.2014.10.008 .
Suljovrujić, Edin H., Mićić, Maja M., "Smart poly(oligo(propylene glycol) methacrylate) hydrogel prepared by gamma radiation" in Nuclear Instruments and Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 342 (2015):206-214, https://doi.org/10.1016/j.nimb.2014.10.008 . .