Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b] quinoline
Апстракт
The title compound, C(14)H(14)ClN, is a chloro analogue of tacrine, an acetylcholinesterase inhibitor. The compound comprises a seven-membered alicyclic ring whose CH donor groups are engaged in extensive intermolecular interactions. The important feature of this crystal structure is that, regardless of the presence of two typical hydrogen-bonding acceptors, viz. chlorine and nitrogen, the corresponding C-H H center dot center dot center dot Cl and C-H center dot center dot center dot N interactions take no significant role in crystal stabilization. The molecules form dimers through pi-pi interactions with an interplanar distance between interacting pyridine rings of 3.576 (1) angstrom. Within the dimers, the molecules are additionally interconnected by four C-H center dot center dot center dot pi interactions. The dimers arrange into regular columns via further intermolecular C-H center dot center dot center dot pi interactions.
Извор:
Acta Crystallographica. Section C: Crystal Structure Communications, 2008, 64, O502-O504Финансирање / пројекти:
- Ministry of Science of the Republic of Serbia [142010]
DOI: 10.1107/S0108270108022221
ISSN: 0108-2701
PubMed: 18758020
WoS: 000258830100015
Scopus: 2-s2.0-51049120943
Колекције
Институција/група
VinčaTY - JOUR AU - Novaković, Slađana B. AU - Vitorović-Todorović, Maja D. AU - Bogdanović, Goran A. AU - Drakulić, Branko J. PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3510 AB - The title compound, C(14)H(14)ClN, is a chloro analogue of tacrine, an acetylcholinesterase inhibitor. The compound comprises a seven-membered alicyclic ring whose CH donor groups are engaged in extensive intermolecular interactions. The important feature of this crystal structure is that, regardless of the presence of two typical hydrogen-bonding acceptors, viz. chlorine and nitrogen, the corresponding C-H H center dot center dot center dot Cl and C-H center dot center dot center dot N interactions take no significant role in crystal stabilization. The molecules form dimers through pi-pi interactions with an interplanar distance between interacting pyridine rings of 3.576 (1) angstrom. Within the dimers, the molecules are additionally interconnected by four C-H center dot center dot center dot pi interactions. The dimers arrange into regular columns via further intermolecular C-H center dot center dot center dot pi interactions. T2 - Acta Crystallographica. Section C: Crystal Structure Communications T1 - Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b] quinoline VL - 64 SP - O502 EP - O504 DO - 10.1107/S0108270108022221 ER -
@article{ author = "Novaković, Slađana B. and Vitorović-Todorović, Maja D. and Bogdanović, Goran A. and Drakulić, Branko J.", year = "2008", abstract = "The title compound, C(14)H(14)ClN, is a chloro analogue of tacrine, an acetylcholinesterase inhibitor. The compound comprises a seven-membered alicyclic ring whose CH donor groups are engaged in extensive intermolecular interactions. The important feature of this crystal structure is that, regardless of the presence of two typical hydrogen-bonding acceptors, viz. chlorine and nitrogen, the corresponding C-H H center dot center dot center dot Cl and C-H center dot center dot center dot N interactions take no significant role in crystal stabilization. The molecules form dimers through pi-pi interactions with an interplanar distance between interacting pyridine rings of 3.576 (1) angstrom. Within the dimers, the molecules are additionally interconnected by four C-H center dot center dot center dot pi interactions. The dimers arrange into regular columns via further intermolecular C-H center dot center dot center dot pi interactions.", journal = "Acta Crystallographica. Section C: Crystal Structure Communications", title = "Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b] quinoline", volume = "64", pages = "O502-O504", doi = "10.1107/S0108270108022221" }
Novaković, S. B., Vitorović-Todorović, M. D., Bogdanović, G. A.,& Drakulić, B. J.. (2008). Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b] quinoline. in Acta Crystallographica. Section C: Crystal Structure Communications, 64, O502-O504. https://doi.org/10.1107/S0108270108022221
Novaković SB, Vitorović-Todorović MD, Bogdanović GA, Drakulić BJ. Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b] quinoline. in Acta Crystallographica. Section C: Crystal Structure Communications. 2008;64:O502-O504. doi:10.1107/S0108270108022221 .
Novaković, Slađana B., Vitorović-Todorović, Maja D., Bogdanović, Goran A., Drakulić, Branko J., "Weak intermolecular interactions in 11-chloro-2,3,4,5-tetrahydro-1H-cyclohepta[b] quinoline" in Acta Crystallographica. Section C: Crystal Structure Communications, 64 (2008):O502-O504, https://doi.org/10.1107/S0108270108022221 . .