Properties of grape seed Proanthocyanidins and quercetin in human lymphocytes
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This study addresses the in vitro protective effects of proanthocyanidins and quercetin on the frequency of micronuclei with reference to the antioxidant status of cultured human lymphocytes also subjected to 2 Gy of gamma-radiation. Treatment of lymphocytes with proanthocyanidins induced a significant decrease in the frequency of micronuclei and reduction of malonyldialdehyde production, as well as increased catalase and glutathione S-transferase activity Quercetin induces a higher incidence of micronuclei and production of malonyldialdehyde. The seven-fold increase of micronuclei frequency induced by a therapeutic dose of gamma-radiation was decreased in the presence of proanthocyanidins. These results demonstrate that proanthocyanidins may be important in the prevention of ROS-induced oxidative lymphocyte damage by decreasing DNA damage, lowering membrane lipid peroxidation, and increasing the activity AOP enzymes, as well as by reducing the level of gamma-radiation-induced DNA dama...ge. Our results support the potential benefits of proanthocyanidins as efficient antioxidants and radioprotectors.
Кључне речи:micronucleus test / flavonoids / malonyldialdehyde / catalase / glutathione S-transferase / gamma-radiation / human lymphocytes
Извор:Archives of biological sciences, 2008, 60, 3, 367-377
- Serbian Ministry of Science [143044B]