Serum cortisol and insulin concentrations in dogs naturally infected with Babesia canis
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Matijatko, VesnaTorti, Mann
Kis, Ivana
Smit, Iva
Stokovic, Igor
Vranješ-Đurić, Sanja
Milanovic, Svetlana
Mrljak, Vladimir
Brkljacic, Mirna
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Babesiosis is an emerging tick-transmitted infectious disease of vertebrates that occurs worldwide. In Europe the predominant cause of canine babesiosis is Babesia canis. The disease can be clinically classified into uncomplicated and complicated forms. Both uncomplicated and complicated babesiosis due to Babesia canis appear to be the result of host inflammatory responses. The main aim of this study was to investigate the endocrine anti-inflammatory response in dogs naturally infected with Babesia canis. It was demonstrated that a marked endocrine response occurs in dogs naturally infected with Babesia canis, with significant increases in the concentration of cortisol and insulin. Statistically significant differences were found between the studied groups for all variables (cortisol, insulin and glucose) before the antibabesial treatment. The day after treatment a statistically significant difference was found between healthy dogs and the dogs that survived, as well as the dogs that d...ied, for cortisol and glucose, but not for insulin. In all of the studied dog groups the median value of glucose was within the reference range, but one animal within the group of dogs that survived was hypoglycemic before the antibabesial treatment. After the antibabesial treatment all the studied animals had glucose values within the reference range. A statistically significant positive correlation was found between cortisol and insulin. The results of this study showed that concentrations of cortisol and insulin can be used to predict mortality in canine babesiosis caused by B. canis.
Keywords:
endocrine response / compensatory anti-inflammatory response syndrome / dogs / babesiosis / insulin / cortisolSource:
Veterinarski Arhiv, 2014, 84, 6, 551-562Funding / projects:
- Ministry of Science, Education and Sports of the Republic of Croatia [053-0532266-2220]
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VinčaTY - JOUR AU - Matijatko, Vesna AU - Torti, Mann AU - Kis, Ivana AU - Smit, Iva AU - Stokovic, Igor AU - Vranješ-Đurić, Sanja AU - Milanovic, Svetlana AU - Mrljak, Vladimir AU - Brkljacic, Mirna PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/348 AB - Babesiosis is an emerging tick-transmitted infectious disease of vertebrates that occurs worldwide. In Europe the predominant cause of canine babesiosis is Babesia canis. The disease can be clinically classified into uncomplicated and complicated forms. Both uncomplicated and complicated babesiosis due to Babesia canis appear to be the result of host inflammatory responses. The main aim of this study was to investigate the endocrine anti-inflammatory response in dogs naturally infected with Babesia canis. It was demonstrated that a marked endocrine response occurs in dogs naturally infected with Babesia canis, with significant increases in the concentration of cortisol and insulin. Statistically significant differences were found between the studied groups for all variables (cortisol, insulin and glucose) before the antibabesial treatment. The day after treatment a statistically significant difference was found between healthy dogs and the dogs that survived, as well as the dogs that died, for cortisol and glucose, but not for insulin. In all of the studied dog groups the median value of glucose was within the reference range, but one animal within the group of dogs that survived was hypoglycemic before the antibabesial treatment. After the antibabesial treatment all the studied animals had glucose values within the reference range. A statistically significant positive correlation was found between cortisol and insulin. The results of this study showed that concentrations of cortisol and insulin can be used to predict mortality in canine babesiosis caused by B. canis. T2 - Veterinarski Arhiv T1 - Serum cortisol and insulin concentrations in dogs naturally infected with Babesia canis VL - 84 IS - 6 SP - 551 EP - 562 UR - https://hdl.handle.net/21.15107/rcub_vinar_348 ER -
@article{ author = "Matijatko, Vesna and Torti, Mann and Kis, Ivana and Smit, Iva and Stokovic, Igor and Vranješ-Đurić, Sanja and Milanovic, Svetlana and Mrljak, Vladimir and Brkljacic, Mirna", year = "2014", abstract = "Babesiosis is an emerging tick-transmitted infectious disease of vertebrates that occurs worldwide. In Europe the predominant cause of canine babesiosis is Babesia canis. The disease can be clinically classified into uncomplicated and complicated forms. Both uncomplicated and complicated babesiosis due to Babesia canis appear to be the result of host inflammatory responses. The main aim of this study was to investigate the endocrine anti-inflammatory response in dogs naturally infected with Babesia canis. It was demonstrated that a marked endocrine response occurs in dogs naturally infected with Babesia canis, with significant increases in the concentration of cortisol and insulin. Statistically significant differences were found between the studied groups for all variables (cortisol, insulin and glucose) before the antibabesial treatment. The day after treatment a statistically significant difference was found between healthy dogs and the dogs that survived, as well as the dogs that died, for cortisol and glucose, but not for insulin. In all of the studied dog groups the median value of glucose was within the reference range, but one animal within the group of dogs that survived was hypoglycemic before the antibabesial treatment. After the antibabesial treatment all the studied animals had glucose values within the reference range. A statistically significant positive correlation was found between cortisol and insulin. The results of this study showed that concentrations of cortisol and insulin can be used to predict mortality in canine babesiosis caused by B. canis.", journal = "Veterinarski Arhiv", title = "Serum cortisol and insulin concentrations in dogs naturally infected with Babesia canis", volume = "84", number = "6", pages = "551-562", url = "https://hdl.handle.net/21.15107/rcub_vinar_348" }
Matijatko, V., Torti, M., Kis, I., Smit, I., Stokovic, I., Vranješ-Đurić, S., Milanovic, S., Mrljak, V.,& Brkljacic, M.. (2014). Serum cortisol and insulin concentrations in dogs naturally infected with Babesia canis. in Veterinarski Arhiv, 84(6), 551-562. https://hdl.handle.net/21.15107/rcub_vinar_348
Matijatko V, Torti M, Kis I, Smit I, Stokovic I, Vranješ-Đurić S, Milanovic S, Mrljak V, Brkljacic M. Serum cortisol and insulin concentrations in dogs naturally infected with Babesia canis. in Veterinarski Arhiv. 2014;84(6):551-562. https://hdl.handle.net/21.15107/rcub_vinar_348 .
Matijatko, Vesna, Torti, Mann, Kis, Ivana, Smit, Iva, Stokovic, Igor, Vranješ-Đurić, Sanja, Milanovic, Svetlana, Mrljak, Vladimir, Brkljacic, Mirna, "Serum cortisol and insulin concentrations in dogs naturally infected with Babesia canis" in Veterinarski Arhiv, 84, no. 6 (2014):551-562, https://hdl.handle.net/21.15107/rcub_vinar_348 .