Radioprotective effects of Gentianella austriaca fractions and polyphenolic constituents in human lymphocytes
Нема приказа
Аутори
Janković, TeodoraSavikin, Katarina
Menkovic, Nebojsa
Aljancic, Ivana
Leskovac, Andreja
Petrović, Sandra
Joksić, Gordana
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to identify active principles of Gentianella austriaca responsible for the reduction of the incidence of micronuclei in irradiated lymphocytes in vitro. The radioprotective effects of ether (EF) and methanolic (MeF) fractions, water-soluble xanthones demethylbellidifolin (1), demethylbellidifolin 8-O-glucoside (2), bellidifolin 8-O-glucoside (3), and flavonoid swertisin (4) against chromosomal damage induced by gamma-rays were determined using the micronucleus test. EF and MeF showed better protection in treatment of human lymphocytes after gamma-irradiation than did isolated compounds. Among the isolated compounds, the effectivenessin reduction of the frequency of micronuclei followed the order 4 GT 3 GT 2 GT 1. The anti-lipoperoxidant activity was in the order 2 GT 4 GT 1, while 3 slightly increased the level of malondialdehyde. In addition, the effectiveness in induction of apoptosis followed the order, 3 GT 2 GT 4, while 1 had no proapoptotic effect. These... results suggest that the antioxidative properties of the polyphenols tested may contribute to the radioprotective effects of G. austriaca.
Кључне речи:
Gentianella austriaca / Gentianaceae / xanthones / radioprotection / micronucleiИзвор:
Planta Medica, 2008, 74, 7, 736-740
DOI: 10.1055/s-2008-1074524
ISSN: 0032-0943
PubMed: 18446672
WoS: 000257284700006
Scopus: 2-s2.0-45849147001
Колекције
Институција/група
VinčaTY - JOUR AU - Janković, Teodora AU - Savikin, Katarina AU - Menkovic, Nebojsa AU - Aljancic, Ivana AU - Leskovac, Andreja AU - Petrović, Sandra AU - Joksić, Gordana PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3482 AB - The aim of this study was to identify active principles of Gentianella austriaca responsible for the reduction of the incidence of micronuclei in irradiated lymphocytes in vitro. The radioprotective effects of ether (EF) and methanolic (MeF) fractions, water-soluble xanthones demethylbellidifolin (1), demethylbellidifolin 8-O-glucoside (2), bellidifolin 8-O-glucoside (3), and flavonoid swertisin (4) against chromosomal damage induced by gamma-rays were determined using the micronucleus test. EF and MeF showed better protection in treatment of human lymphocytes after gamma-irradiation than did isolated compounds. Among the isolated compounds, the effectivenessin reduction of the frequency of micronuclei followed the order 4 GT 3 GT 2 GT 1. The anti-lipoperoxidant activity was in the order 2 GT 4 GT 1, while 3 slightly increased the level of malondialdehyde. In addition, the effectiveness in induction of apoptosis followed the order, 3 GT 2 GT 4, while 1 had no proapoptotic effect. These results suggest that the antioxidative properties of the polyphenols tested may contribute to the radioprotective effects of G. austriaca. T2 - Planta Medica T1 - Radioprotective effects of Gentianella austriaca fractions and polyphenolic constituents in human lymphocytes VL - 74 IS - 7 SP - 736 EP - 740 DO - 10.1055/s-2008-1074524 ER -
@article{ author = "Janković, Teodora and Savikin, Katarina and Menkovic, Nebojsa and Aljancic, Ivana and Leskovac, Andreja and Petrović, Sandra and Joksić, Gordana", year = "2008", abstract = "The aim of this study was to identify active principles of Gentianella austriaca responsible for the reduction of the incidence of micronuclei in irradiated lymphocytes in vitro. The radioprotective effects of ether (EF) and methanolic (MeF) fractions, water-soluble xanthones demethylbellidifolin (1), demethylbellidifolin 8-O-glucoside (2), bellidifolin 8-O-glucoside (3), and flavonoid swertisin (4) against chromosomal damage induced by gamma-rays were determined using the micronucleus test. EF and MeF showed better protection in treatment of human lymphocytes after gamma-irradiation than did isolated compounds. Among the isolated compounds, the effectivenessin reduction of the frequency of micronuclei followed the order 4 GT 3 GT 2 GT 1. The anti-lipoperoxidant activity was in the order 2 GT 4 GT 1, while 3 slightly increased the level of malondialdehyde. In addition, the effectiveness in induction of apoptosis followed the order, 3 GT 2 GT 4, while 1 had no proapoptotic effect. These results suggest that the antioxidative properties of the polyphenols tested may contribute to the radioprotective effects of G. austriaca.", journal = "Planta Medica", title = "Radioprotective effects of Gentianella austriaca fractions and polyphenolic constituents in human lymphocytes", volume = "74", number = "7", pages = "736-740", doi = "10.1055/s-2008-1074524" }
Janković, T., Savikin, K., Menkovic, N., Aljancic, I., Leskovac, A., Petrović, S.,& Joksić, G.. (2008). Radioprotective effects of Gentianella austriaca fractions and polyphenolic constituents in human lymphocytes. in Planta Medica, 74(7), 736-740. https://doi.org/10.1055/s-2008-1074524
Janković T, Savikin K, Menkovic N, Aljancic I, Leskovac A, Petrović S, Joksić G. Radioprotective effects of Gentianella austriaca fractions and polyphenolic constituents in human lymphocytes. in Planta Medica. 2008;74(7):736-740. doi:10.1055/s-2008-1074524 .
Janković, Teodora, Savikin, Katarina, Menkovic, Nebojsa, Aljancic, Ivana, Leskovac, Andreja, Petrović, Sandra, Joksić, Gordana, "Radioprotective effects of Gentianella austriaca fractions and polyphenolic constituents in human lymphocytes" in Planta Medica, 74, no. 7 (2008):736-740, https://doi.org/10.1055/s-2008-1074524 . .