Приказ основних података о документу

dc.creatorVasiljević, Radivoje
dc.creatorVeljković, Veljko
dc.creatorGlišić, V.
dc.date.accessioned2018-03-01T20:25:07Z
dc.date.available2018-03-01T20:25:07Z
dc.date.issued2008
dc.identifier.issn0042-9007
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/3441
dc.description.abstractTransferrin receptor 1 (TfR1) is key molecule involved in the accumu-lation of hepatic iron in chronic hepatitis C (HCV). TfR1 is constitutivelyclustered in coated pits and can be rapidly internalized, transported to theacidic endosome, and recycled back to the cell surface. It was alsoproposed that TfR1 is involved in infection of hepatocytes by participa-tion in internalization of E2 protein – major receptor binding protein ofthe HCV. We investigated the role of TfR1 in HCV cell entry, using theinformational spectrum method (ISM), a virtual spectroscopy method forstructure/function analysis of nucleotide and protein sequences. Resultsof the ISM analysis indicate (i) that TfR1 is involved in viral entry viaclatrin associated endocytosis, and (ii) the direct interaction betweenextracellular domain of TfR1 and E2 protein. These results suggestpossible additional role of TfR1, beyond the role in internalization, inHCV receptor cell entry.en
dc.rightsrestrictedAccessen
dc.sourceVox Sanguinisen
dc.titleThe role of transferrin receptor 1 in HCV infectionen
dc.typeconferenceObjecten
dc.rights.licenseARR
dcterms.abstractВасиљевиц, Р.; Глисиц, В; Вељковић Вељко;
dc.citation.volume95
dc.citation.issueSuppl: 1
dc.citation.spage271
dc.identifier.wos000255665700655
dc.identifier.doi10.1111/j.1423-0410.2008.01056.x
dc.citation.otherSuppl: 1
dc.citation.rankM22
dc.type.versionpublishedVersion
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_vinar_3441


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Приказ основних података о документу