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The influence of malathion and its decomposition products on free and immobilized acetylcholinesterase
dc.creator | Krstić, Danijela Z. | |
dc.creator | Čolović, Mirjana B. | |
dc.creator | Kralj, M. B. | |
dc.creator | Trebše, Polonca | |
dc.creator | Krinulović, Katarina | |
dc.creator | Vasić, Vesna M. | |
dc.date.accessioned | 2018-03-01T20:23:25Z | |
dc.date.available | 2018-03-01T20:23:25Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0036-0244 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3421 | |
dc.description.abstract | The influence of malathion and its four main degradation products found in irradiated solutions (malaoxon, isomalathion, diethyl maleate and O,O-dimethyl phosphate) on acetylcholinesterase (AChE) of free and immobilized bovine erythrocytes was investigated. The concentration-dependent responses to malathion and related organophosphates, malaoxon and isomalathion, of both AChE bioassays used were obtained. The IC (50) values for free and immobilized AChE (3.7 +/- 0.2) x 10(-4) M/(1.6 +/- 0.1) x 10(-4), (2.4 +/- 0.3) x 10(-6)/(3.4 +/- 0.1) x 10(-6) M, and (3.2 +/- 0.3) x 10(-6) M/(2.7 +/- 0.2) x 10(-6) M were obtained in the presence of malathion, malaoxon and isomalathion, respectively. However, diethyl maleate inhibited AChE activity at concentrations GT = 10 mM, while O,O-dimethyl phosphate did not noticeably affect enzyme activity at all investigated concentrations. The relation between the structure of the compounds and their ability to inhibit enzyme activity was discussed. | en |
dc.rights | restrictedAccess | en |
dc.source | Russian Journal of Physical Chemistry A | en |
dc.title | The influence of malathion and its decomposition products on free and immobilized acetylcholinesterase | en |
dc.type | article | en |
dcterms.abstract | Крстиц, Д.; Кринуловиц, К.; Краљ, М. Б.; Требсе, П.; Чоловић Мирјана; Васић Весна М; | |
dc.citation.volume | 82 | |
dc.citation.issue | 4 | |
dc.citation.spage | 663 | |
dc.citation.epage | 668 | |
dc.identifier.wos | 000254939300027 | |
dc.identifier.doi | 10.1134/S0036024408040274 | |
dc.citation.rank | M23 |
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WoS Import
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050 - Laboratorija za fizičku hemiju
Department of Physical Chemistry