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dc.creatorStanojević, Boban
dc.creatorSaenko, Vladimir
dc.creatorTodorović, Lidija
dc.creatorPetrović, Nina
dc.creatorNikolic, Dragan
dc.creatorZivaljevic, Vladan
dc.creatorPaunovic, Ivan
dc.creatorNakashima, Masahiro
dc.creatorYamashita, Shunichi
dc.creatorDzodic, Radan
dc.date.accessioned2018-03-01T15:48:14Z
dc.date.available2018-03-01T15:48:14Z
dc.date.issued2014
dc.identifier.issn1932-6203 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/340
dc.description.abstractAlterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR=5.78, 95% CI 3.17-10.53, P LT 0.0001), classical papillary morphology of the tumor (OR=2.92, 95% CI 1.33-6.44, P=0.008) and multifocality (OR=1.96, 95% CI 1.06-3.62, P=0.031). In disease-free survival analysis, low VHL expression had marginal significance (P=0.0502 by the log-rank test) but did not appear to be an independent predictor of the risk for chance of faster recurrence in a proportion hazards model. No somatic mutations or evidence of VHL downregulation via promoter hypermethylation in PTC were found. The results indicate that the decrease of VHL expression associates with tumor progression but the mechanism of downregulation remains to be elucidated.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173049/RS//
dc.relationNagasaki University Global COE Program
dc.rightsopenAccessen
dc.sourcePLoS Oneen
dc.titleLow VHL mRNA Expression is Associated with More Aggressive Tumor Features of Papillary Thyroid Carcinomaen
dc.typearticleen
dcterms.abstractYамасхита, Схуницхи; Тодоровић Лидија; Станојевић Бобан; Дзодиц, Радан; Петровић Нина; Пауновиц, Иван; Накасхима, Масахиро; Николиц, Драган; Саенко, Владимир; Зиваљевиц, Владан;
dc.citation.volume9
dc.citation.issue12
dc.identifier.wos000347515300045
dc.identifier.doi10.1371/journal.pone.0114511
dc.citation.otherArticle Number: e114511
dc.citation.rankM21
dc.identifier.pmid25490036
dc.identifier.scopus2-s2.0-84916641841


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