Show simple item record

dc.creatorSpasojević, Nataša
dc.creatorGavrilović, Ljubica
dc.creatorDronjak, Slađana
dc.date.accessioned2018-03-01T20:22:13Z
dc.date.available2018-03-01T20:22:13Z
dc.date.issued2008
dc.identifier.issn0354-4664 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/3407
dc.description.abstractSerotonin and noradrenaline are involved in the mechanisms of action of most antidepressant drugs. We examined the effects of chronic treatment with maprotiline, a selective inhibitor of noradrenaline reuptake, and fluxilan, a selective inhibitor of serotonin reuptake, on the behavior of unstressed controls and chronic unpredictable mild stress (CUMS) model rats in the forced swim test (FST) and elevated plus maze test. Both selective reuptake inhibitors resulted in a significant reduction of time spent in immobility. Climbing was significantly increased in maprotiline- and swimming was exclusively elicited in the fluxilan-treated unstressed control and CUMS rats. Maprotiline-treated animals displayed decreased anxiety and fluxilan-treated rats enhanced anxiety. The obtained results suggest that central noradrenergic and serotonergic systems might be affected differently during FST. The results also demonstrate that the anxiogenic effects of chronic fluxilan treatment are similar to those reported by many other studies. These differences observed for the effects of fluxilan in relation to those reported for maprotiline and probably due to the different pharmacological profiles of these drugs.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143044/RS//
dc.rightsopenAccessen
dc.sourceArchives of biological sciencesen
dc.subjectbehavioren
dc.subjectratsen
dc.subjectantidepressantsen
dc.subjectmonoamine reuptake inhibitorsen
dc.titleDifferent behavioral effects of maprotiline and fluxilan in ratsen
dc.typearticleen
dcterms.abstractСпасојевић Наташа; Гавриловић Љубица; Дроњак Слађана;
dc.citation.volume60
dc.citation.issue1
dc.citation.spage33
dc.citation.epage39
dc.identifier.wos000254813700006
dc.identifier.doi10.2298/ABS0801033S
dc.identifier.scopus2-s2.0-53549090423
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/12455/3403.pdf


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record