X-linked angiotensin II type 2 receptor gene polymorphism-1332A/G in male patients with essential hypertension
Apstrakt
Background: The role of AT2R in regulation of blood pressure (BP) was mainly investigated in animal models. It is proposed to be a negative regulator of BP. X-linked AT2R -1332 A/G polymorphism has been denoted as functional. This polymorphism was associated with certain cardiovascular phenotypes in hypertensive patients, but it was poorly investigated in essential hypertension. The aim of our study was to evaluate possible association of -1332 A/G gene polymorphism with essential hypertension in males from Serbian population. Methods: The study group included 304 men of Caucasian origin, 190 normotensive (NT) and 114 hypertensive (HT), free of cardiovascular disorders. Genotyping was done by PCR RFLP method. Results: G/- genotype was in association with HT (OR 1.6, CI = 1.0-2.6, p = 0.04). Stratification by age ( LT 40 years, mean 31.65 +/- 5.29 and GT 40 years, mean 51.36 +/- 8.32) pronounced significance only in older males (OR 2.4, CI = 1.2-5.0, p = 0.02). After adjustment for conf...ounding factors the OR for hypertension remained unchanged and significant (adjusted OR 2.3, CI = 1.0-5.4, p = 0.04). Conclusion: Hemizygosity for the G allele was found to be susceptibility factor for hypertension in males. Still, clarifying the role of AT2R in development of human hypertension requires further replication studies in larger and different populations. (C) 2007 Elsevier B.V. All rights reserved.
Ključne reči:
AT2 receptor / gene / polymorphism / hypertension / malesIzvor:
Clinica Chimica Acta, 2007, 386, 1-2, 110-113
DOI: 10.1016/j.cca.2007.07.014
ISSN: 0009-8981
PubMed: 17707359
WoS: 000250195700019
Scopus: 2-s2.0-34548725470
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Živković, Maja AU - Đurić, Tamara AU - Stančić, Ja AU - Alavantić, Dragan AU - Stanković, Aleksandra PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3306 AB - Background: The role of AT2R in regulation of blood pressure (BP) was mainly investigated in animal models. It is proposed to be a negative regulator of BP. X-linked AT2R -1332 A/G polymorphism has been denoted as functional. This polymorphism was associated with certain cardiovascular phenotypes in hypertensive patients, but it was poorly investigated in essential hypertension. The aim of our study was to evaluate possible association of -1332 A/G gene polymorphism with essential hypertension in males from Serbian population. Methods: The study group included 304 men of Caucasian origin, 190 normotensive (NT) and 114 hypertensive (HT), free of cardiovascular disorders. Genotyping was done by PCR RFLP method. Results: G/- genotype was in association with HT (OR 1.6, CI = 1.0-2.6, p = 0.04). Stratification by age ( LT 40 years, mean 31.65 +/- 5.29 and GT 40 years, mean 51.36 +/- 8.32) pronounced significance only in older males (OR 2.4, CI = 1.2-5.0, p = 0.02). After adjustment for confounding factors the OR for hypertension remained unchanged and significant (adjusted OR 2.3, CI = 1.0-5.4, p = 0.04). Conclusion: Hemizygosity for the G allele was found to be susceptibility factor for hypertension in males. Still, clarifying the role of AT2R in development of human hypertension requires further replication studies in larger and different populations. (C) 2007 Elsevier B.V. All rights reserved. T2 - Clinica Chimica Acta T1 - X-linked angiotensin II type 2 receptor gene polymorphism-1332A/G in male patients with essential hypertension VL - 386 IS - 1-2 SP - 110 EP - 113 DO - 10.1016/j.cca.2007.07.014 ER -
@article{ author = "Živković, Maja and Đurić, Tamara and Stančić, Ja and Alavantić, Dragan and Stanković, Aleksandra", year = "2007", abstract = "Background: The role of AT2R in regulation of blood pressure (BP) was mainly investigated in animal models. It is proposed to be a negative regulator of BP. X-linked AT2R -1332 A/G polymorphism has been denoted as functional. This polymorphism was associated with certain cardiovascular phenotypes in hypertensive patients, but it was poorly investigated in essential hypertension. The aim of our study was to evaluate possible association of -1332 A/G gene polymorphism with essential hypertension in males from Serbian population. Methods: The study group included 304 men of Caucasian origin, 190 normotensive (NT) and 114 hypertensive (HT), free of cardiovascular disorders. Genotyping was done by PCR RFLP method. Results: G/- genotype was in association with HT (OR 1.6, CI = 1.0-2.6, p = 0.04). Stratification by age ( LT 40 years, mean 31.65 +/- 5.29 and GT 40 years, mean 51.36 +/- 8.32) pronounced significance only in older males (OR 2.4, CI = 1.2-5.0, p = 0.02). After adjustment for confounding factors the OR for hypertension remained unchanged and significant (adjusted OR 2.3, CI = 1.0-5.4, p = 0.04). Conclusion: Hemizygosity for the G allele was found to be susceptibility factor for hypertension in males. Still, clarifying the role of AT2R in development of human hypertension requires further replication studies in larger and different populations. (C) 2007 Elsevier B.V. All rights reserved.", journal = "Clinica Chimica Acta", title = "X-linked angiotensin II type 2 receptor gene polymorphism-1332A/G in male patients with essential hypertension", volume = "386", number = "1-2", pages = "110-113", doi = "10.1016/j.cca.2007.07.014" }
Živković, M., Đurić, T., Stančić, J., Alavantić, D.,& Stanković, A.. (2007). X-linked angiotensin II type 2 receptor gene polymorphism-1332A/G in male patients with essential hypertension. in Clinica Chimica Acta, 386(1-2), 110-113. https://doi.org/10.1016/j.cca.2007.07.014
Živković M, Đurić T, Stančić J, Alavantić D, Stanković A. X-linked angiotensin II type 2 receptor gene polymorphism-1332A/G in male patients with essential hypertension. in Clinica Chimica Acta. 2007;386(1-2):110-113. doi:10.1016/j.cca.2007.07.014 .
Živković, Maja, Đurić, Tamara, Stančić, Ja, Alavantić, Dragan, Stanković, Aleksandra, "X-linked angiotensin II type 2 receptor gene polymorphism-1332A/G in male patients with essential hypertension" in Clinica Chimica Acta, 386, no. 1-2 (2007):110-113, https://doi.org/10.1016/j.cca.2007.07.014 . .