Toward novel HIV-1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies
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The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC50 = 12 mu M (C) 2007 Elsevier Ltd. All rights reserved.
Кључне речи:HIV-1 / integrase inhibitors
Извор:Bioorganic and Medicinal Chemistry Letters, 2007, 17, 19, 5370-5373
ISSN: 0960-894X (print)