Behavioural and endocrine responses of socially isolated rats to long-term diazepam treatment
Apstrakt
The effects of diazepam (0.2 mg/kg/ during 21 days, i.p.) on behaviour, pituitary-adrenocortical and sympatho-adrenomedullary system of socially isolated and group-housed adult male rats additionally exposed to immobilization, were studied. Social isolation led to a shorter duration of grooming and longer latency to start grooming. Diazepam in social isolated rats reduced incorrect transitions percentage, but the number of grooming bouts, duration and latency to start grooming remained unchanged. Long-term isolation significantly elevated plasma ACTH and corticosterone, while not affecting noradrenaline and adrenaline. Diazepam decreased only plasma ACTH. Social isolation and immobilization significantly elevated all examined hormones. Immobilization of diazepam-treated isolated rats enhanced plasma ACTH, the increase being significantly lower, comparing to isolated vehicle-treated rats. Immobilization significantly increased plasma adrenaline, noradrenaline and corticosterone of diaze...pam- or vehicle-treated socially isolated rats. No differences in adrenaline, noradrenaline and corticosterone level between these two groups were observed. This indicates that chronic diazepam treatment of socially isolated rats changes some grooming behaviour parameters, but insignificantly affects stress-related adrenomedullary and adrenocortical alterations.
Ključne reči:
words : diazepam / social isolation / grooming / catecholamines / corticosterone / ACTHIzvor:
Acta Veterinaria, Beograd, 2007, 57, 4, 291-302Finansiranje / projekti:
- Signalni putevi delovanja steroidnih hormona i uticaj endogenih i egzogenih faktora na modulaciju procesa u ćelijama sisara (RS-MESTD-MPN2006-2010-143044)
DOI: 10.2298/AVB0704291D
ISSN: 0567-8315; 1820-7448
WoS: 000249713600001
Scopus: 2-s2.0-35248863423
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Dronjak, Slađana AU - Spasojević, Nataša AU - Gavrilović, Ljubica AU - Varagic, V. PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3283 AB - The effects of diazepam (0.2 mg/kg/ during 21 days, i.p.) on behaviour, pituitary-adrenocortical and sympatho-adrenomedullary system of socially isolated and group-housed adult male rats additionally exposed to immobilization, were studied. Social isolation led to a shorter duration of grooming and longer latency to start grooming. Diazepam in social isolated rats reduced incorrect transitions percentage, but the number of grooming bouts, duration and latency to start grooming remained unchanged. Long-term isolation significantly elevated plasma ACTH and corticosterone, while not affecting noradrenaline and adrenaline. Diazepam decreased only plasma ACTH. Social isolation and immobilization significantly elevated all examined hormones. Immobilization of diazepam-treated isolated rats enhanced plasma ACTH, the increase being significantly lower, comparing to isolated vehicle-treated rats. Immobilization significantly increased plasma adrenaline, noradrenaline and corticosterone of diazepam- or vehicle-treated socially isolated rats. No differences in adrenaline, noradrenaline and corticosterone level between these two groups were observed. This indicates that chronic diazepam treatment of socially isolated rats changes some grooming behaviour parameters, but insignificantly affects stress-related adrenomedullary and adrenocortical alterations. T2 - Acta Veterinaria, Beograd T1 - Behavioural and endocrine responses of socially isolated rats to long-term diazepam treatment VL - 57 IS - 4 SP - 291 EP - 302 DO - 10.2298/AVB0704291D ER -
@article{ author = "Dronjak, Slađana and Spasojević, Nataša and Gavrilović, Ljubica and Varagic, V.", year = "2007", abstract = "The effects of diazepam (0.2 mg/kg/ during 21 days, i.p.) on behaviour, pituitary-adrenocortical and sympatho-adrenomedullary system of socially isolated and group-housed adult male rats additionally exposed to immobilization, were studied. Social isolation led to a shorter duration of grooming and longer latency to start grooming. Diazepam in social isolated rats reduced incorrect transitions percentage, but the number of grooming bouts, duration and latency to start grooming remained unchanged. Long-term isolation significantly elevated plasma ACTH and corticosterone, while not affecting noradrenaline and adrenaline. Diazepam decreased only plasma ACTH. Social isolation and immobilization significantly elevated all examined hormones. Immobilization of diazepam-treated isolated rats enhanced plasma ACTH, the increase being significantly lower, comparing to isolated vehicle-treated rats. Immobilization significantly increased plasma adrenaline, noradrenaline and corticosterone of diazepam- or vehicle-treated socially isolated rats. No differences in adrenaline, noradrenaline and corticosterone level between these two groups were observed. This indicates that chronic diazepam treatment of socially isolated rats changes some grooming behaviour parameters, but insignificantly affects stress-related adrenomedullary and adrenocortical alterations.", journal = "Acta Veterinaria, Beograd", title = "Behavioural and endocrine responses of socially isolated rats to long-term diazepam treatment", volume = "57", number = "4", pages = "291-302", doi = "10.2298/AVB0704291D" }
Dronjak, S., Spasojević, N., Gavrilović, L.,& Varagic, V.. (2007). Behavioural and endocrine responses of socially isolated rats to long-term diazepam treatment. in Acta Veterinaria, Beograd, 57(4), 291-302. https://doi.org/10.2298/AVB0704291D
Dronjak S, Spasojević N, Gavrilović L, Varagic V. Behavioural and endocrine responses of socially isolated rats to long-term diazepam treatment. in Acta Veterinaria, Beograd. 2007;57(4):291-302. doi:10.2298/AVB0704291D .
Dronjak, Slađana, Spasojević, Nataša, Gavrilović, Ljubica, Varagic, V., "Behavioural and endocrine responses of socially isolated rats to long-term diazepam treatment" in Acta Veterinaria, Beograd, 57, no. 4 (2007):291-302, https://doi.org/10.2298/AVB0704291D . .