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Lsm proteins bind and stabilize RNAs containing 5 poly(A) tracts
dc.creator | Bergman, Naomi | |
dc.creator | Moraes, Karen C. M. | |
dc.creator | Anderson, John R. | |
dc.creator | Zarić, Božidarka | |
dc.creator | Kambach, Christian | |
dc.creator | Schneider, Robert J. | |
dc.creator | Wilusz, Carol J. | |
dc.creator | Wilusz, Jeffrey | |
dc.date.accessioned | 2018-03-01T20:11:11Z | |
dc.date.available | 2018-03-01T20:11:11Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1545-9985 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/3277 | |
dc.description.abstract | Many orthopoxvirus messenger RNAs have an unusual nontemplated poly( A) tract of 5 to 40 residues at the 5 end. The precise function of this feature is unknown. Here we show that 5 poly( A) tracts are able to repress RNA decay by inhibiting 3 - to- 5 exonucleases as well as decapping of RNA substrates. UV cross- linking analysis demonstrated that the Lsm complex associates with the 5 poly( A) tract. Furthermore, recombinant Lsm1 - 7 complex specifically binds 5 poly( A) tracts 10 to 21 nucleotides in length, consistent with the length of 5 poly( A) required for stabilization. Knockdown of Lsm1 abrogates RNA stabilization by the 5 poly( A) tract. We propose that the Lsm complex simultaneously binds the 3 and 5 ends of these unusual messenger RNAs and thereby prevents 3 - to-5 decay. The implications of this phenomenon for cellular mRNA decay are discussed. | en |
dc.relation | NIGMS NIH HHS [GM72481] | |
dc.rights | restrictedAccess | en |
dc.source | Nature Structural and Molecular Biology | en |
dc.title | Lsm proteins bind and stabilize RNAs containing 5 poly(A) tracts | en |
dc.type | article | en |
dcterms.abstract | Бергман, Наоми; Мораес, Карен Ц. М.; Aндерсон, Јохн Р.; Камбацх, Цхристиан; Wилусз, Царол Ј.; Wилусз, Јеффреy; Зарић Божидарка; Сцхнеидер, Роберт Ј.; | |
dc.citation.volume | 14 | |
dc.citation.issue | 9 | |
dc.citation.spage | 824 | |
dc.citation.epage | 831 | |
dc.identifier.wos | 000249276500009 | |
dc.identifier.doi | 10.1038/nsmb1287 | |
dc.citation.rank | M21a | |
dc.identifier.pmid | 17694069 | |
dc.identifier.scopus | 2-s2.0-34548472407 |
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