Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats
Апстракт
In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Psychosocial stress produced a significant increase of both TH mRNA and DBH mRNA levels in stellate ganglia. Additional immobilization of long-term psychosocially stressed rats expressed no effect on gene expression of these enzymes. The results presented here suggest that psychosocial stress-induced increase in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia may be connected to the increased risk of cardiovascular disease. (C) 2009 Elsevier B.V. All rights reserved.
Кључне речи:
Stellate ganglia / Psychosocial stress / Norepinephrine / Gene expressionИзвор:
Autonomic Neuroscience: Basic and Clinical, 2009, 150, 1-2, 144-146Финансирање / пројекти:
- Сигнални путеви деловања стероидних хормона и утицај ендогених и егзогених фактора на модулацију процеса у ћелијама сисара (RS-MESTD-MPN2006-2010-143044)
DOI: 10.1016/j.autneu.2009.05.242
ISSN: 1566-0702
PubMed: 19482560
WoS: 000270472800022
Scopus: 2-s2.0-69449097215
Колекције
Институција/група
VinčaTY - JOUR AU - Gavrilović, Ljubica AU - Spasojević, Nataša AU - Dronjak, Slađana PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3252 AB - In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Psychosocial stress produced a significant increase of both TH mRNA and DBH mRNA levels in stellate ganglia. Additional immobilization of long-term psychosocially stressed rats expressed no effect on gene expression of these enzymes. The results presented here suggest that psychosocial stress-induced increase in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia may be connected to the increased risk of cardiovascular disease. (C) 2009 Elsevier B.V. All rights reserved. T2 - Autonomic Neuroscience: Basic and Clinical T1 - Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats VL - 150 IS - 1-2 SP - 144 EP - 146 DO - 10.1016/j.autneu.2009.05.242 ER -
@article{ author = "Gavrilović, Ljubica and Spasojević, Nataša and Dronjak, Slađana", year = "2009", abstract = "In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Psychosocial stress produced a significant increase of both TH mRNA and DBH mRNA levels in stellate ganglia. Additional immobilization of long-term psychosocially stressed rats expressed no effect on gene expression of these enzymes. The results presented here suggest that psychosocial stress-induced increase in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia may be connected to the increased risk of cardiovascular disease. (C) 2009 Elsevier B.V. All rights reserved.", journal = "Autonomic Neuroscience: Basic and Clinical", title = "Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats", volume = "150", number = "1-2", pages = "144-146", doi = "10.1016/j.autneu.2009.05.242" }
Gavrilović, L., Spasojević, N.,& Dronjak, S.. (2009). Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats. in Autonomic Neuroscience: Basic and Clinical, 150(1-2), 144-146. https://doi.org/10.1016/j.autneu.2009.05.242
Gavrilović L, Spasojević N, Dronjak S. Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats. in Autonomic Neuroscience: Basic and Clinical. 2009;150(1-2):144-146. doi:10.1016/j.autneu.2009.05.242 .
Gavrilović, Ljubica, Spasojević, Nataša, Dronjak, Slađana, "Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats" in Autonomic Neuroscience: Basic and Clinical, 150, no. 1-2 (2009):144-146, https://doi.org/10.1016/j.autneu.2009.05.242 . .