Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia
Нема приказа
Аутори
Đurić, TamaraŽivković, Maja
Stanković, Aleksandra
Dinčić, Evica
Raičević, Ranko
Alavantić, Dragan
Чланак у часопису
Метаподаци
Приказ свих података о документуАпстракт
Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in remodeling of the extracellular matrix. MMPs are suggested to play a role in the influx of inflammatory cells into the CNS, disruption of the blood brain barrier, and to degrade myelin in vitro. In this study, we have investigated the possible association of MMP-3 5A/6A gene polymorphism with MS susceptibility and/or severity in patients from Serbia. A total of 184 MS patients (150 RR, 34 SP) and 236 controls have been studied. Results show that the distribution of MMP-3 5A/6A genotype frequencies between NIS patients and controls were not significantly different. In bout onset patients, carriers of MMP-3 6A/6A genotype had significantly higher mean MSSS values compared to the carriers of 5A allele (6.29 +/- 1.89 vs. 5.29 +/- 2.62, respectively, ANCOVA, p=0.01 Scheffe post-hoc test). In conclusion, our results indicate association of MMP-3 6A/6A genotype with significantly higher mean MSSS values. Thus, the obtained r...esults suggest that it should be carefully considered during follow up of patients with MS. Further genetic and functional studies are needed to resolve the complex role of MMPs and their tissue inhibitors in NIS pathology and/or regeneration. (C) 2007 Elsevier B.V. All rights reserved.
Кључне речи:
MMP-3 / gene polymorphism / multiple sclerosis / MSSSИзвор:
Journal of the Neurological Sciences, 2008, 267, 1-2, 62-65
DOI: 10.1016/j.jns.2007.09.037
ISSN: 0022-510X
PubMed: 17942123
WoS: 000254180600010
Scopus: 2-s2.0-39149105944
Колекције
Институција/група
VinčaTY - JOUR AU - Đurić, Tamara AU - Živković, Maja AU - Stanković, Aleksandra AU - Dinčić, Evica AU - Raičević, Ranko AU - Alavantić, Dragan PY - 2008 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3237 AB - Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in remodeling of the extracellular matrix. MMPs are suggested to play a role in the influx of inflammatory cells into the CNS, disruption of the blood brain barrier, and to degrade myelin in vitro. In this study, we have investigated the possible association of MMP-3 5A/6A gene polymorphism with MS susceptibility and/or severity in patients from Serbia. A total of 184 MS patients (150 RR, 34 SP) and 236 controls have been studied. Results show that the distribution of MMP-3 5A/6A genotype frequencies between NIS patients and controls were not significantly different. In bout onset patients, carriers of MMP-3 6A/6A genotype had significantly higher mean MSSS values compared to the carriers of 5A allele (6.29 +/- 1.89 vs. 5.29 +/- 2.62, respectively, ANCOVA, p=0.01 Scheffe post-hoc test). In conclusion, our results indicate association of MMP-3 6A/6A genotype with significantly higher mean MSSS values. Thus, the obtained results suggest that it should be carefully considered during follow up of patients with MS. Further genetic and functional studies are needed to resolve the complex role of MMPs and their tissue inhibitors in NIS pathology and/or regeneration. (C) 2007 Elsevier B.V. All rights reserved. T2 - Journal of the Neurological Sciences T1 - Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia VL - 267 IS - 1-2 SP - 62 EP - 65 DO - 10.1016/j.jns.2007.09.037 ER -
@article{ author = "Đurić, Tamara and Živković, Maja and Stanković, Aleksandra and Dinčić, Evica and Raičević, Ranko and Alavantić, Dragan", year = "2008", abstract = "Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in remodeling of the extracellular matrix. MMPs are suggested to play a role in the influx of inflammatory cells into the CNS, disruption of the blood brain barrier, and to degrade myelin in vitro. In this study, we have investigated the possible association of MMP-3 5A/6A gene polymorphism with MS susceptibility and/or severity in patients from Serbia. A total of 184 MS patients (150 RR, 34 SP) and 236 controls have been studied. Results show that the distribution of MMP-3 5A/6A genotype frequencies between NIS patients and controls were not significantly different. In bout onset patients, carriers of MMP-3 6A/6A genotype had significantly higher mean MSSS values compared to the carriers of 5A allele (6.29 +/- 1.89 vs. 5.29 +/- 2.62, respectively, ANCOVA, p=0.01 Scheffe post-hoc test). In conclusion, our results indicate association of MMP-3 6A/6A genotype with significantly higher mean MSSS values. Thus, the obtained results suggest that it should be carefully considered during follow up of patients with MS. Further genetic and functional studies are needed to resolve the complex role of MMPs and their tissue inhibitors in NIS pathology and/or regeneration. (C) 2007 Elsevier B.V. All rights reserved.", journal = "Journal of the Neurological Sciences", title = "Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia", volume = "267", number = "1-2", pages = "62-65", doi = "10.1016/j.jns.2007.09.037" }
Đurić, T., Živković, M., Stanković, A., Dinčić, E., Raičević, R.,& Alavantić, D.. (2008). Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia. in Journal of the Neurological Sciences, 267(1-2), 62-65. https://doi.org/10.1016/j.jns.2007.09.037
Đurić T, Živković M, Stanković A, Dinčić E, Raičević R, Alavantić D. Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia. in Journal of the Neurological Sciences. 2008;267(1-2):62-65. doi:10.1016/j.jns.2007.09.037 .
Đurić, Tamara, Živković, Maja, Stanković, Aleksandra, Dinčić, Evica, Raičević, Ranko, Alavantić, Dragan, "Association of the MMP-3 5A/6A gene polymorphism with multiple sclerosis in patients from Serbia" in Journal of the Neurological Sciences, 267, no. 1-2 (2008):62-65, https://doi.org/10.1016/j.jns.2007.09.037 . .