Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes
Apstrakt
Insulin-like growth factor-1 (IGF-1) is a hormone and growth factor closely related to insulin. The autocrine/paracrine actions of IGF-1 involve activation of inducible nitric oxide synthase (iNOS) and the Na(+), K(+)-ATPase sodium pump in cardiovascular tissues. Data from literature indicate that iNOS is expressed in vascular smooth muscle cells (VSMC) and that IGF- 1 -induced release of NO is both rapid and delayed. We hypothesize that impaired IGF-1 -induced sodium pump activity/ expression in rats with type 1 diabetes is related to activation of phosphatidytinositol 3 kinase (PI3K)/cytosolic phospholipase 2 (cPLA(2))/protein kinase B (Akt) signaling, and that IGF-1 prevents acute and chronic dysfunction of iNOS and sodium pump activity in a chemically induced model of type 1 diabetes, the streptozotocin -treated rat heart (STZ). Understanding how iNOS and sodium pump activity are regulated by IGF-1 activation of the PI3K/cPLA(2)/Akt cascade should provide novel and fundamental know...ledge regarding the regulatory actions of IGF-1 in promoting vasodilation. Since insulin resistance is currently a major focus of research, the use of IGF-1 to improve insulin resistance and glucose metabolism has opened a new arena for treatment of comorbid conditions. Future investigations should now focus on mechanisms of action of IGF-1 and its clinical applicability. (c) 2007 Elsevier Ltd. All rights reserved.
Izvor:
Medical Hypotheses, 2007, 69, 2, 302-306
DOI: 10.1016/j.mehy.2006.11.045
ISSN: 0306-9877
PubMed: 17289286
WoS: 000247683800012
Scopus: 2-s2.0-34249730961
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Žakula, Zorica AU - Korićanac, Goran AU - Putniković, Biljana AU - Markovic, Ljiljana AU - Isenović, Esma R. PY - 2007 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3205 AB - Insulin-like growth factor-1 (IGF-1) is a hormone and growth factor closely related to insulin. The autocrine/paracrine actions of IGF-1 involve activation of inducible nitric oxide synthase (iNOS) and the Na(+), K(+)-ATPase sodium pump in cardiovascular tissues. Data from literature indicate that iNOS is expressed in vascular smooth muscle cells (VSMC) and that IGF- 1 -induced release of NO is both rapid and delayed. We hypothesize that impaired IGF-1 -induced sodium pump activity/ expression in rats with type 1 diabetes is related to activation of phosphatidytinositol 3 kinase (PI3K)/cytosolic phospholipase 2 (cPLA(2))/protein kinase B (Akt) signaling, and that IGF-1 prevents acute and chronic dysfunction of iNOS and sodium pump activity in a chemically induced model of type 1 diabetes, the streptozotocin -treated rat heart (STZ). Understanding how iNOS and sodium pump activity are regulated by IGF-1 activation of the PI3K/cPLA(2)/Akt cascade should provide novel and fundamental knowledge regarding the regulatory actions of IGF-1 in promoting vasodilation. Since insulin resistance is currently a major focus of research, the use of IGF-1 to improve insulin resistance and glucose metabolism has opened a new arena for treatment of comorbid conditions. Future investigations should now focus on mechanisms of action of IGF-1 and its clinical applicability. (c) 2007 Elsevier Ltd. All rights reserved. T2 - Medical Hypotheses T1 - Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes VL - 69 IS - 2 SP - 302 EP - 306 DO - 10.1016/j.mehy.2006.11.045 ER -
@article{ author = "Žakula, Zorica and Korićanac, Goran and Putniković, Biljana and Markovic, Ljiljana and Isenović, Esma R.", year = "2007", abstract = "Insulin-like growth factor-1 (IGF-1) is a hormone and growth factor closely related to insulin. The autocrine/paracrine actions of IGF-1 involve activation of inducible nitric oxide synthase (iNOS) and the Na(+), K(+)-ATPase sodium pump in cardiovascular tissues. Data from literature indicate that iNOS is expressed in vascular smooth muscle cells (VSMC) and that IGF- 1 -induced release of NO is both rapid and delayed. We hypothesize that impaired IGF-1 -induced sodium pump activity/ expression in rats with type 1 diabetes is related to activation of phosphatidytinositol 3 kinase (PI3K)/cytosolic phospholipase 2 (cPLA(2))/protein kinase B (Akt) signaling, and that IGF-1 prevents acute and chronic dysfunction of iNOS and sodium pump activity in a chemically induced model of type 1 diabetes, the streptozotocin -treated rat heart (STZ). Understanding how iNOS and sodium pump activity are regulated by IGF-1 activation of the PI3K/cPLA(2)/Akt cascade should provide novel and fundamental knowledge regarding the regulatory actions of IGF-1 in promoting vasodilation. Since insulin resistance is currently a major focus of research, the use of IGF-1 to improve insulin resistance and glucose metabolism has opened a new arena for treatment of comorbid conditions. Future investigations should now focus on mechanisms of action of IGF-1 and its clinical applicability. (c) 2007 Elsevier Ltd. All rights reserved.", journal = "Medical Hypotheses", title = "Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes", volume = "69", number = "2", pages = "302-306", doi = "10.1016/j.mehy.2006.11.045" }
Žakula, Z., Korićanac, G., Putniković, B., Markovic, L.,& Isenović, E. R.. (2007). Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes. in Medical Hypotheses, 69(2), 302-306. https://doi.org/10.1016/j.mehy.2006.11.045
Žakula Z, Korićanac G, Putniković B, Markovic L, Isenović ER. Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes. in Medical Hypotheses. 2007;69(2):302-306. doi:10.1016/j.mehy.2006.11.045 .
Žakula, Zorica, Korićanac, Goran, Putniković, Biljana, Markovic, Ljiljana, Isenović, Esma R., "Regulation of the inducible nitric oxide synthase and sodium pump in type 1 diabetes" in Medical Hypotheses, 69, no. 2 (2007):302-306, https://doi.org/10.1016/j.mehy.2006.11.045 . .