The biological effectiveness of antiproton irradiation
Нема приказа
Аутори
Holzscheiter, Michael H.Bassler, Niels
Agazaryan, Nzhde
Beyer, Gerd
Btackmore, Ewart
DeMarco, John J.
Doser, Michael
Durand, Ralph E.
Hartley, Oliver
Iwamoto, Keisuke S.
Knudsen, Helge V.
Landua, Rolf
Maggiore, Carl
McBride, William H.
Moller, Soren Pape
Petersen, Jorgen
Skarsgard, Lloyd D.
Smathers, James B.
Solberg, Timothy D.
Uggerhoj, Ulrik I.
Vranješ, Sanja
Withers, H. Rodney
Wong, Michelle
Wouters, Bradly G.
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Background and purpose: Antiprotons travel through tissue in a manner similar to that for protons until they reach the end of their range where they annihilate and deposit additional energy. This makes them potentially interesting for radiotherapy. The aim of this study was to conduct the first ever measurements of the biological effectiveness of antiprotons. Materials and methods: V79 cells were suspended in a semi-solid matrix and irradiated with 46.7 MeV antiprotons, 48 MeV protons, or Co-60 gamma-rays. Clonogenic survival was determined as a function of depth along the particle beams. Dose and particle fluence response relationships were constructed from data in the plateau and Bragg peak regions of the beams and used to assess the biological effectiveness. Results: Due to uncertainties in antiproton dosimetry we defined a new term, called the biologically effective dose ratio (BEDR), which compares the response in a minimally spread out Bragg peak (SOBP) to that in the plateau as ...a function of particle fluence. This value was similar to 3.75 times larger for antiprotons than for protons. This increase arises due to the increased dose deposited in the Bragg peak by annihilation and because this dose has a higher relative biological effectiveness (RBE). Conclusion: We have produced the first measurements of the biological consequences of antiproton irradiation. These data substantiate theoretical predictions of the biological effects of antiproton annihilation within the Bragg peak, and suggest antiprotons warrant further investigation. (c) 2006 Elsevier Ireland Ltd. All. rights reserved.
Кључне речи:
antiproton / RBE / particle irradiation / high LETИзвор:
Radiotherapy and Oncology, 2006, 81, 3, 233-242
DOI: 10.1016/j.radonc.2006.09.012
ISSN: 0167-8140
PubMed: 17069916
WoS: 000243210700003
Scopus: 2-s2.0-33845193549
Колекције
Институција/група
VinčaTY - JOUR AU - Holzscheiter, Michael H. AU - Bassler, Niels AU - Agazaryan, Nzhde AU - Beyer, Gerd AU - Btackmore, Ewart AU - DeMarco, John J. AU - Doser, Michael AU - Durand, Ralph E. AU - Hartley, Oliver AU - Iwamoto, Keisuke S. AU - Knudsen, Helge V. AU - Landua, Rolf AU - Maggiore, Carl AU - McBride, William H. AU - Moller, Soren Pape AU - Petersen, Jorgen AU - Skarsgard, Lloyd D. AU - Smathers, James B. AU - Solberg, Timothy D. AU - Uggerhoj, Ulrik I. AU - Vranješ, Sanja AU - Withers, H. Rodney AU - Wong, Michelle AU - Wouters, Bradly G. PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3136 AB - Background and purpose: Antiprotons travel through tissue in a manner similar to that for protons until they reach the end of their range where they annihilate and deposit additional energy. This makes them potentially interesting for radiotherapy. The aim of this study was to conduct the first ever measurements of the biological effectiveness of antiprotons. Materials and methods: V79 cells were suspended in a semi-solid matrix and irradiated with 46.7 MeV antiprotons, 48 MeV protons, or Co-60 gamma-rays. Clonogenic survival was determined as a function of depth along the particle beams. Dose and particle fluence response relationships were constructed from data in the plateau and Bragg peak regions of the beams and used to assess the biological effectiveness. Results: Due to uncertainties in antiproton dosimetry we defined a new term, called the biologically effective dose ratio (BEDR), which compares the response in a minimally spread out Bragg peak (SOBP) to that in the plateau as a function of particle fluence. This value was similar to 3.75 times larger for antiprotons than for protons. This increase arises due to the increased dose deposited in the Bragg peak by annihilation and because this dose has a higher relative biological effectiveness (RBE). Conclusion: We have produced the first measurements of the biological consequences of antiproton irradiation. These data substantiate theoretical predictions of the biological effects of antiproton annihilation within the Bragg peak, and suggest antiprotons warrant further investigation. (c) 2006 Elsevier Ireland Ltd. All. rights reserved. T2 - Radiotherapy and Oncology T1 - The biological effectiveness of antiproton irradiation VL - 81 IS - 3 SP - 233 EP - 242 DO - 10.1016/j.radonc.2006.09.012 ER -
@article{ author = "Holzscheiter, Michael H. and Bassler, Niels and Agazaryan, Nzhde and Beyer, Gerd and Btackmore, Ewart and DeMarco, John J. and Doser, Michael and Durand, Ralph E. and Hartley, Oliver and Iwamoto, Keisuke S. and Knudsen, Helge V. and Landua, Rolf and Maggiore, Carl and McBride, William H. and Moller, Soren Pape and Petersen, Jorgen and Skarsgard, Lloyd D. and Smathers, James B. and Solberg, Timothy D. and Uggerhoj, Ulrik I. and Vranješ, Sanja and Withers, H. Rodney and Wong, Michelle and Wouters, Bradly G.", year = "2006", abstract = "Background and purpose: Antiprotons travel through tissue in a manner similar to that for protons until they reach the end of their range where they annihilate and deposit additional energy. This makes them potentially interesting for radiotherapy. The aim of this study was to conduct the first ever measurements of the biological effectiveness of antiprotons. Materials and methods: V79 cells were suspended in a semi-solid matrix and irradiated with 46.7 MeV antiprotons, 48 MeV protons, or Co-60 gamma-rays. Clonogenic survival was determined as a function of depth along the particle beams. Dose and particle fluence response relationships were constructed from data in the plateau and Bragg peak regions of the beams and used to assess the biological effectiveness. Results: Due to uncertainties in antiproton dosimetry we defined a new term, called the biologically effective dose ratio (BEDR), which compares the response in a minimally spread out Bragg peak (SOBP) to that in the plateau as a function of particle fluence. This value was similar to 3.75 times larger for antiprotons than for protons. This increase arises due to the increased dose deposited in the Bragg peak by annihilation and because this dose has a higher relative biological effectiveness (RBE). Conclusion: We have produced the first measurements of the biological consequences of antiproton irradiation. These data substantiate theoretical predictions of the biological effects of antiproton annihilation within the Bragg peak, and suggest antiprotons warrant further investigation. (c) 2006 Elsevier Ireland Ltd. All. rights reserved.", journal = "Radiotherapy and Oncology", title = "The biological effectiveness of antiproton irradiation", volume = "81", number = "3", pages = "233-242", doi = "10.1016/j.radonc.2006.09.012" }
Holzscheiter, M. H., Bassler, N., Agazaryan, N., Beyer, G., Btackmore, E., DeMarco, J. J., Doser, M., Durand, R. E., Hartley, O., Iwamoto, K. S., Knudsen, H. V., Landua, R., Maggiore, C., McBride, W. H., Moller, S. P., Petersen, J., Skarsgard, L. D., Smathers, J. B., Solberg, T. D., Uggerhoj, U. I., Vranješ, S., Withers, H. R., Wong, M.,& Wouters, B. G.. (2006). The biological effectiveness of antiproton irradiation. in Radiotherapy and Oncology, 81(3), 233-242. https://doi.org/10.1016/j.radonc.2006.09.012
Holzscheiter MH, Bassler N, Agazaryan N, Beyer G, Btackmore E, DeMarco JJ, Doser M, Durand RE, Hartley O, Iwamoto KS, Knudsen HV, Landua R, Maggiore C, McBride WH, Moller SP, Petersen J, Skarsgard LD, Smathers JB, Solberg TD, Uggerhoj UI, Vranješ S, Withers HR, Wong M, Wouters BG. The biological effectiveness of antiproton irradiation. in Radiotherapy and Oncology. 2006;81(3):233-242. doi:10.1016/j.radonc.2006.09.012 .
Holzscheiter, Michael H., Bassler, Niels, Agazaryan, Nzhde, Beyer, Gerd, Btackmore, Ewart, DeMarco, John J., Doser, Michael, Durand, Ralph E., Hartley, Oliver, Iwamoto, Keisuke S., Knudsen, Helge V., Landua, Rolf, Maggiore, Carl, McBride, William H., Moller, Soren Pape, Petersen, Jorgen, Skarsgard, Lloyd D., Smathers, James B., Solberg, Timothy D., Uggerhoj, Ulrik I., Vranješ, Sanja, Withers, H. Rodney, Wong, Michelle, Wouters, Bradly G., "The biological effectiveness of antiproton irradiation" in Radiotherapy and Oncology, 81, no. 3 (2006):233-242, https://doi.org/10.1016/j.radonc.2006.09.012 . .