Inactivation of nanocrystalline C-60 cytotoxicity by gamma-irradiation
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Isaković, Aleksandra J.Marković, Zoran M.
Nikolić, Nadežda S.
Todorović-Marković, Biljana
Vranješ-Đurić, Sanja
Harhaji, Ljubica M.
Raičević, Nevena
Romčević, Nebojša Ž.
Vasiljević-Radović, Dana
Dramićanin, Miroslav
Trajković, Vladimir S.
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We investigated the effect of gamma-irradiation on the cytotoxicity of pure C-60 solubilized in water by using tetrahydrofuran (THF/n-C-60 or THF/n-C-60). In contrast to THF/n-C-60, its gamma-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, gamma-irradiated THF/n-C-60 protected cells from the oxidative stress induced by native THF/n-C-60 or hydrogen peroxide. The observed biological effects were associated with of THF and subsequent derivatization of the n-C-60 surface. These results for the first time demonstrate gamma-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C-60, resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:
carbon / nanoparticle / gamma irradiation / cytotoxicity / antioxidantSource:
Biomaterials, 2006, 27, 29, 5049-5058
DOI: 10.1016/j.biomaterials.2006.05.047
ISSN: 0142-9612
PubMed: 16784774
WoS: 000240167500005
Scopus: 2-s2.0-33745272220
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VinčaTY - JOUR AU - Isaković, Aleksandra J. AU - Marković, Zoran M. AU - Nikolić, Nadežda S. AU - Todorović-Marković, Biljana AU - Vranješ-Đurić, Sanja AU - Harhaji, Ljubica M. AU - Raičević, Nevena AU - Romčević, Nebojša Ž. AU - Vasiljević-Radović, Dana AU - Dramićanin, Miroslav AU - Trajković, Vladimir S. PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3076 AB - We investigated the effect of gamma-irradiation on the cytotoxicity of pure C-60 solubilized in water by using tetrahydrofuran (THF/n-C-60 or THF/n-C-60). In contrast to THF/n-C-60, its gamma-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, gamma-irradiated THF/n-C-60 protected cells from the oxidative stress induced by native THF/n-C-60 or hydrogen peroxide. The observed biological effects were associated with of THF and subsequent derivatization of the n-C-60 surface. These results for the first time demonstrate gamma-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C-60, resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent. (c) 2006 Elsevier Ltd. All rights reserved. T2 - Biomaterials T1 - Inactivation of nanocrystalline C-60 cytotoxicity by gamma-irradiation VL - 27 IS - 29 SP - 5049 EP - 5058 DO - 10.1016/j.biomaterials.2006.05.047 ER -
@article{ author = "Isaković, Aleksandra J. and Marković, Zoran M. and Nikolić, Nadežda S. and Todorović-Marković, Biljana and Vranješ-Đurić, Sanja and Harhaji, Ljubica M. and Raičević, Nevena and Romčević, Nebojša Ž. and Vasiljević-Radović, Dana and Dramićanin, Miroslav and Trajković, Vladimir S.", year = "2006", abstract = "We investigated the effect of gamma-irradiation on the cytotoxicity of pure C-60 solubilized in water by using tetrahydrofuran (THF/n-C-60 or THF/n-C-60). In contrast to THF/n-C-60, its gamma-irradiated counterpart failed to generate oxygen radicals and cause extracellular signal-regulated kinase (ERK)-dependent necrotic cell death in various types of mammalian cells. Moreover, gamma-irradiated THF/n-C-60 protected cells from the oxidative stress induced by native THF/n-C-60 or hydrogen peroxide. The observed biological effects were associated with of THF and subsequent derivatization of the n-C-60 surface. These results for the first time demonstrate gamma-irradiation-mediated changes in the physico-chemical properties of THF-prepared nanocrystalline C-60, resulting in a complete loss of its cytotoxic effect and its conversion to a cytoprotective agent. (c) 2006 Elsevier Ltd. All rights reserved.", journal = "Biomaterials", title = "Inactivation of nanocrystalline C-60 cytotoxicity by gamma-irradiation", volume = "27", number = "29", pages = "5049-5058", doi = "10.1016/j.biomaterials.2006.05.047" }
Isaković, A. J., Marković, Z. M., Nikolić, N. S., Todorović-Marković, B., Vranješ-Đurić, S., Harhaji, L. M., Raičević, N., Romčević, N. Ž., Vasiljević-Radović, D., Dramićanin, M.,& Trajković, V. S.. (2006). Inactivation of nanocrystalline C-60 cytotoxicity by gamma-irradiation. in Biomaterials, 27(29), 5049-5058. https://doi.org/10.1016/j.biomaterials.2006.05.047
Isaković AJ, Marković ZM, Nikolić NS, Todorović-Marković B, Vranješ-Đurić S, Harhaji LM, Raičević N, Romčević NŽ, Vasiljević-Radović D, Dramićanin M, Trajković VS. Inactivation of nanocrystalline C-60 cytotoxicity by gamma-irradiation. in Biomaterials. 2006;27(29):5049-5058. doi:10.1016/j.biomaterials.2006.05.047 .
Isaković, Aleksandra J., Marković, Zoran M., Nikolić, Nadežda S., Todorović-Marković, Biljana, Vranješ-Đurić, Sanja, Harhaji, Ljubica M., Raičević, Nevena, Romčević, Nebojša Ž., Vasiljević-Radović, Dana, Dramićanin, Miroslav, Trajković, Vladimir S., "Inactivation of nanocrystalline C-60 cytotoxicity by gamma-irradiation" in Biomaterials, 27, no. 29 (2006):5049-5058, https://doi.org/10.1016/j.biomaterials.2006.05.047 . .