Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models
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Аутори
Pajović, Snežana B.Pejić, Snežana
Stojiljković, Vesna
Gavrilović, Ljubica
Dronjak, Slađana
Kanazir, Dušan T.
Чланак у часопису
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The study deals with activity of three antioxidant enzymes, copper, zinc-superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), catalase (CAT) in hippocampus of rats, following the exposure to single chronic (individual housing or forced swimming) and acute (immobilization or cold) stress, as well as to combined chronic/acute stress. In addition, plasma noradrenaline (NA) and adrenaline (A) concentrations were measured in the same stress conditions, because their autooxidation can add to the oxidative stress. We observed that i) long-term social isolation and repeated forced swimming had minor effects on plasma catecholamines, but in the long-term pretreated groups, acute stressors caused profound elevation NA and A levels, ii) chronic stressors activate antioxidant enzymes, iii) acute stressors decrease catalase activity, their effects on CuZnSOD appear to be stressor-dependent, whereas MnSOD is not affected by acute stressors, and iv) pre-exposure to chronic stress a...ffects the antioxidant-related effects of acute stressors, but this effect depends to a large extent on the type of the chronic stressor. Based on both metabolic and neuroendocrine data, long-term isolation appears to be a robust psychological stressor and to induce a priming effect specifically on the CuZnSOD and CAT activity.
Кључне речи:
stress / hippocampus / antioxidant enzymes / catecholaminesИзвор:
Physiological Research, 2006, 55, 4, 453-460Институција/група
VinčaTY - JOUR AU - Pajović, Snežana B. AU - Pejić, Snežana AU - Stojiljković, Vesna AU - Gavrilović, Ljubica AU - Dronjak, Slađana AU - Kanazir, Dušan T. PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/3075 AB - The study deals with activity of three antioxidant enzymes, copper, zinc-superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), catalase (CAT) in hippocampus of rats, following the exposure to single chronic (individual housing or forced swimming) and acute (immobilization or cold) stress, as well as to combined chronic/acute stress. In addition, plasma noradrenaline (NA) and adrenaline (A) concentrations were measured in the same stress conditions, because their autooxidation can add to the oxidative stress. We observed that i) long-term social isolation and repeated forced swimming had minor effects on plasma catecholamines, but in the long-term pretreated groups, acute stressors caused profound elevation NA and A levels, ii) chronic stressors activate antioxidant enzymes, iii) acute stressors decrease catalase activity, their effects on CuZnSOD appear to be stressor-dependent, whereas MnSOD is not affected by acute stressors, and iv) pre-exposure to chronic stress affects the antioxidant-related effects of acute stressors, but this effect depends to a large extent on the type of the chronic stressor. Based on both metabolic and neuroendocrine data, long-term isolation appears to be a robust psychological stressor and to induce a priming effect specifically on the CuZnSOD and CAT activity. T2 - Physiological Research T1 - Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models VL - 55 IS - 4 SP - 453 EP - 460 UR - https://hdl.handle.net/21.15107/rcub_vinar_3075 ER -
@article{ author = "Pajović, Snežana B. and Pejić, Snežana and Stojiljković, Vesna and Gavrilović, Ljubica and Dronjak, Slađana and Kanazir, Dušan T.", year = "2006", abstract = "The study deals with activity of three antioxidant enzymes, copper, zinc-superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), catalase (CAT) in hippocampus of rats, following the exposure to single chronic (individual housing or forced swimming) and acute (immobilization or cold) stress, as well as to combined chronic/acute stress. In addition, plasma noradrenaline (NA) and adrenaline (A) concentrations were measured in the same stress conditions, because their autooxidation can add to the oxidative stress. We observed that i) long-term social isolation and repeated forced swimming had minor effects on plasma catecholamines, but in the long-term pretreated groups, acute stressors caused profound elevation NA and A levels, ii) chronic stressors activate antioxidant enzymes, iii) acute stressors decrease catalase activity, their effects on CuZnSOD appear to be stressor-dependent, whereas MnSOD is not affected by acute stressors, and iv) pre-exposure to chronic stress affects the antioxidant-related effects of acute stressors, but this effect depends to a large extent on the type of the chronic stressor. Based on both metabolic and neuroendocrine data, long-term isolation appears to be a robust psychological stressor and to induce a priming effect specifically on the CuZnSOD and CAT activity.", journal = "Physiological Research", title = "Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models", volume = "55", number = "4", pages = "453-460", url = "https://hdl.handle.net/21.15107/rcub_vinar_3075" }
Pajović, S. B., Pejić, S., Stojiljković, V., Gavrilović, L., Dronjak, S.,& Kanazir, D. T.. (2006). Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models. in Physiological Research, 55(4), 453-460. https://hdl.handle.net/21.15107/rcub_vinar_3075
Pajović SB, Pejić S, Stojiljković V, Gavrilović L, Dronjak S, Kanazir DT. Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models. in Physiological Research. 2006;55(4):453-460. https://hdl.handle.net/21.15107/rcub_vinar_3075 .
Pajović, Snežana B., Pejić, Snežana, Stojiljković, Vesna, Gavrilović, Ljubica, Dronjak, Slađana, Kanazir, Dušan T., "Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models" in Physiological Research, 55, no. 4 (2006):453-460, https://hdl.handle.net/21.15107/rcub_vinar_3075 .